Portsmouth have won just two of their last six games at Fratton Park in league and cup.
Hull City have won six of their last seven Championship away games.
Recommended bet: Hull City to win
Portsmouth are trying to clamber clear of the Championship relegation zone, while Hull City visit Fratton Park attempting to solidify their play-off place.
It was differing midweek outcomes for the two sides as Pompey lost 2-1 at Wrexham and City defeated top-six rivals Derby County 4-2 on Humberside.
The travelling Tigers could be set for yet another away-day victory as they head for the south coast.
The latest Portsmouth vs Hull City odds are available on LiveScore Bet
Team news
Pompey named an unchanged starting XI for the midweek reverse at Wrexham after their wins against Charlton and Millwall.
Fit-again Conor Chaplin, who had missed three games with a groin issue, was back as a sub in north Wales and could return as a starter now.
Midfielder John Swift was withdrawn before half-time and will be assessed, with Adrian Segecic and Harvey Blair amongst those hoping to come in after cameos in midweek.
City lost creative midfielder Ryan Giles in the win over Derby and he is expected to be out for four to six weeks with a hamstring problem.
Meanwhile, Tigers boss Sergej Jakirovic does not expect Bristol City loanee Yu Hirakawa to feature again this season as he is facing an ankle operation.
The stats
There have been 19 goals scored in Hull's last four games and 11 in Portsmouth's last three.
Only Coventry and Middlesbrough enter this round of games with more away points than Hull's 27. The Tigers have won eight away league games from 15, including six of the last seven.
Portsmouth have failed to win any of the last four meetings with Hull (D2, L2) and have won just two of their last six games at Fratton Park in league and cup.
Hull have scored at least twice in 11 of their last 15 away games.
The latest Portsmouth vs Hull City odds are available on LiveScore Bet
Prediction
City's recent Championship blip was arrested in midweek with a 4-2 win over fellow play-off hopefuls Derby, with boss Jakirovic hailing the collective spirit.
It was enough to ensure they start the weekend in fifth, three clear of Wrexham in sixth after the Red Dragons took care of Portsmouth at the Racecourse Ground.
Hull can rise to third, at least temporarily, if they return from the south coast with a ninth away league win in 16 attempts.
Such an outcome would mean they have gathered the most away league points on their travels despite playing fewer games than the likes of Coventry and Middlesbrough.
The Tigers have scored in 15 successive away league and cup games, registering multiple goals in all bar four of those.
This Pompey side are averaging just 1.03 goals per game in the league and may well fall short as a result.
