The top two in the standings meet in Paris, as PSG play host to Bayern Munich
Liverpool welcome Real Madrid to Anfield for another massive clash
Luciano Spalletti takes charge of Juventus against Sporting
We have reached Matchday Four of the Champions League and there are some fantastic games to look forward to across both Tuesday and Wednesday.
In this article, we make predictions on all 18 matches, including Liverpool's home clash with Real Madrid and PSG's encounter with Bayern Munich.
Napoli vs Eintracht Frankfurt (Tuesday, 5:45pm)
Both teams have three points after their opening three games and are just inside the middle third of the standings.
Napoli sit top of Serie A and are unbeaten in their six home games this term, while Eintracht Frankfurt have won just one of their last four fixtures.
Score Prediction: Napoli 2-0 Eintracht Frankfurt
Slavia Prague vs Arsenal (Tuesday, 5:45pm)
Arsenal have a 100% record in Europe this season and head into this clash having also won their last five Premier League games.
Slavia Prague have kept clean sheets in their last four matches, but this is a step up in class of opposition.
Score Prediction: Slavia Prague 0-2 Arsenal
Atletico Madrid vs Union Saint-Gilloise (Tuesday, 8pm)
Both of these two teams have three points from their opening three games, but Atletico Madrid should have too much for their Belgian opponents on home soil.
Diego Simone's men are unbeaten in eight home games this season, which includes wins over Real Madrid and Eintracht Frankfurt.
Score Prediction: Atletico Madrid 3-0 Union Saint-Gilloise
Bodo/Glimt vs Monaco (Tuesday, 8pm)
Both teams have two Champions League draws to their name and it would not be a surprise to see them finish level on Tuesday.
Bodo/Glimt go into this clash after a defeat to Valerenga, while Monaco lost 1-0 at home to Paris FC.
Score Prediction: Bodo/Glimt 1-1 Monaco
Juventus vs Sporting (Tuesday, 8pm)
Juventus play their first European match since parting company with boss Igor Tudor, with Luciano Spalletti taking charge and gaining a win over Cremonese in his first Serie A fixture.
Sporting have won five on the spin in all competitions and have won two of their three Champions League fixtures, but have never won a competitive match in Italy.
Score Prediction: Juventus 2-0 Sporting
Liverpool vs Real Madrid (Tuesday, 8pm)
Real Madrid have won six in a row heading to Anfield on Tuesday, as they face a Liverpool team who ended their five-game domestic losing run against Aston Villa on Saturday.
The Reds beat Real 2-0 in this competition last season, but the Spanish giants have won on their previous two visits to Merseyside.
Score Prediction: Liverpool 2-2 Real Madrid
Olympiakos vs PSV Eindhoven (Tuesday, 8pm)
The hosts have claimed just one point from their first three League format matches, while PSV Eindhoven have four points thanks to a draw and win in their last two fixtures.
Both teams are currently second in their domestic league, Olympiakos have won their last three games and PSV their last five.
Score Prediction: Olyampiakos 1-1 PSV Enidhoven
Paris Saint-Germain vs Bayern Munich (Tuesday 8pm)
The top two in the standings meet in the French capital, with both PSG and Bayern currently having an 100% record.
The hosts have scored more goals than any other team in this season's Champions League (13), while Bayern have scored two or more goals in each of their 15 games this term, having won all of those 15 matches.
Score Prediction: PSG 3-1 Bayern Munich
Tottenham vs FC Copenhagen (Tuesday, 8pm)
Tottenham have scored three goals in their three Champions League games, scoring just twice in their last three home fixtures.
Copenhagen have just one point to their name and lost their previous European away game, 2-0 at Qarabag.
Score Prediction: Tottenham 1-0 Copenhagen
Pafos vs Villarreal (Wednesday, 5:45pm)
Pafos have one more point than Villarreal going into Wednesday's early kick-off, after draws with Olympiakos and Kairat.
Villarreal have won back-to-back La Liga games, which sees them up to third in their domestic league.
Score Prediction: Pafos 0-2 Villarreal
Qarabag vs Chelsea (Wednesday, 5:45pm)
Qarabag have already collected six points from their first three European fixtures and are just two places behind their opponents.
Chelsea have scored in each of their last 14 games in all competitions and should have enough to break down a stubborn home team.
Score Prediction: Qarabag 1-2 Chelsea
Ajax vs Galatasaray (Wednesday, 8pm)
Ajax are one of two teams still looking for their first point after three games, while Galatasaray are sat in 14th with six points.
The Dutch outfit have conceded 23 goals in their last nine games, while the visitors are unbeaten in their last eight matches in all competitions.
Score Prediction: Ajax 1-2 Galatasaray
Benfica vs Bayer Leverkusen (Wednesday, 8pm)
These two sides have made disappointing starts to the European campaign, with zero and two points respectively.
Jose Mourinho takes charge of his first Champions League home tie as Benfica boss and he has only lost one of his four previous meetings with Bayer Leverkusen.
Score Prediction: Benfica 2-1 Bayer Leverkusen
Club Brugge vs Barcelona (Wednesday, 8pm)
Barcelona head to Belgium having lost three of their last six matches, but a win on Wednesday is likely to move them into the top eight.
After an opening game win over Monaco, Brugge have lost their last two in the Champions League and are yet to beat Barcelona in their four previous meetings.
Score Prediction: Club Brugge 1-3 Barcelona
Inter Milan vs Kairat (Wednesday, 8pm)
It has been a 100% start for last season's beaten finalists Inter Milan ahead of the visit of Kairat, who secured their first point in Game Week Three.
Inter have won their last four matches at the San Siro, which includes a 3-0 win over Slavia Prague.
Score Prediction: Inter Milan 4-0 Kairat
Man City vs Borussia Dortmund (Wednesday, 8pm)
Pep Guardiola's men have suffered just one defeat in their last 10 games, with Man City scoring 15 goals in their last five matches at the Etihad.
Borussia Dortmund have already conceded seven times in their opening three Champions League games.
Score Prediction: Man City 3-1 Borussia Dortmund
Marseille vs Atalanta (Wednesday, 8pm)
Marseille have made a strong start to the Ligue 1 season, but have just three points from their opening three Champions League fixtures.
Atalanta head to the south of France having failed to win any of their last six matches.
Score Prediction: Marseille 2-1 Atalanta
Newcastle vs Athletic Bilbao (Wednesday, 8pm)
Newcastle go into this game having lost 3-1 at West Ham, but they have claimed European victories after previous Premier League defeats.
Athletic Bilbao travel to Tyneside sitting 11th in La Liga, having won just one of their last five league games.
Score Prediction: Newcastle 2-0 Athletic Bilbao
