West Ham are playing their first home game under new manager Nuno Espirito Santo
Brentford are bidding for a fourth win in their last five Premier League trips to West Ham
Recommended bet: Brentford to win
Nuno Espirito Santo's West Ham career started with a 1-1 draw at Everton and a 2-0 defeat at Arsenal so he will be desperate to win his first home fixture as Hammers boss on Monday.
Nuno's Nottingham Forest side beat Brentford 3-1 on the opening day of the season but the Bees have a fine record in this fixture.
Kevin Schade's early goal gave them a 1-0 win at West Ham in February and they beat Manchester United 3-1 at the end of September before a 1-0 home defeat to in-form Manchester City last time out.
The latest West Ham vs Brentford odds are available on LiveScore Bet.
Team news
West Ham's Tomas Soucek is available after a three-match ban but Mateus Fernandes and Soungoutou Magassa should start in central midfield.
Callum Wilson is set to lead the line as German striker Niclas Fullkrug is injured while youngster George Earthy (hamstring) is also out.
Brentford's Antoni Milambo is sidelined but full-back Aaron Hickey has recovered from a minor injury suffered on international duty with Scotland.
The latest West Ham vs Brentford odds are available on LiveScore Bet.
The stats
West Ham have conceded 10 goals in their three home defeats this season.
The Hammers have lost six of their eight games in all competitions in 2025-26.
West Ham have been trailing at half-time in their last three matches.
Brentford's first three away games this season were defeats in which both teams scored.
The Bees have won six of their last eight Premier League meetings with West Ham.
Brentford have scored in the first 20 minutes of their last six league clashes with the Hammers.
The latest West Ham vs Brentford odds are available on LiveScore Bet.
Prediction
West Ham's results this season make for grim reading and their only victory in eight matches in all competitions was August's 3-0 win at Nuno's Nottingham Forest.
The home fans at the London Stadium have had little to cheer about, seeing their side slump to three straight defeats against fellow capital clubs.
Chelsea won 5-1 at West Ham in August before Tottenham (3-0) and Crystal Palace (2-1) also claimed three points and Brentford are worth backing for a vital victory on Monday.
West Ham remain hugely reliant on Jarrod Bowen for attacking inspiration. The England international scored their equaliser at Everton in Nuno's first game in charge but the Hammers did not manage a single shot on target at Arsenal last time out.
Brentford have lost their first three away matches under Keith Andrews, going down 3-1 at Forest, 2-1 at Sunderland and 3-1 at Fulham.
However, they won 2-0 at Bournemouth in the Carabao Cup and can take heart from some fine league results at home, where they have beaten Aston Villa and Manchester United and drawn 2-2 with Chelsea.
Home advantage may count for little on Monday given Hammers fans' frustration with the club's owners and Brentford can sour the mood even further.
Striker Igor Thiago needs to sharpen up his finishing if the Bees are to pull clear of relegation trouble but Schade, Dango Ouattara and Mikkel Damsgaard form a talented attacking-midfield trio.
West Ham have struggled to defend crosses into the box — Everton centre-back Michael Keane was the latest opponent to benefit from that vulnerability — and they are hard to fancy in Nuno's home debut.
Back Brentford to win, available at 7/4 with LiveScore Bet.
The latest West Ham vs Brentford odds are available on LiveScore Bet.
