Manchester United bid to follow up win at Liverpool by beating Brighton
Champions Liverpool, who have lost their last three league games, head to Brentford on Saturday evening
Nottingham Forest, under new manager Sean Dyche, travel to in-form Bournemouth on Sunday
The Premier League weekend kicks off on Friday night, when Leeds host struggling West Ham, and there are crucial fixtures at both ends of the table on Saturday and Sunday.
Manchester United host bogey team Brighton while leaders Arsenal welcome Crystal Palace to the Emirates Stadium and survival rivals Wolves and Burnley meet at Molineux.
Leeds vs West Ham (Friday, 8pm)
West Ham have lost all four of their Premier League home games this season but they should be able to play with more freedom away from the London Stadium.
The Hammers have picked up four points on the road and could add to that tally at Leeds, who are also under pressure after last weekend's 2-0 defeat at Burnley.
Score prediction: Leeds 1-1 West Ham
Chelsea vs Sunderland (Saturday, 3pm)
Chelsea's youngsters starred in Wednesday's 5-1 Champions League rout of Ajax and the Blues look set for another entertaining win over Sunderland.
The Black Cats have made a terrific start to the campaign but they have been helped by a soft run of fixtures and could be outclassed at Stamford Bridge.
Score prediction: Chelsea 3-1 Sunderland
Newcastle vs Fulham (Saturday, 3pm)
Newcastle have won three of their last four games to nil, including Tuesday's 3-0 Champions League victory over Jose Mourinho's Benfica.
Fulham failed to land a glove on leaders Arsenal in last weekend's 1-0 loss at Craven Cottage and they were beaten by Aston Villa and Bournemouth in their last two away fixtures.
Score prediction: Newcastle 2-0 Fulham
Manchester United vs Brighton (Saturday, 5.30pm)
Manchester United claimed a memorable 2-1 win over Liverpool at Anfield last weekend but they were fortunate that the Reds missed a host of good chances.
Brighton have won six of their last seven league meetings with United, including 2-1, 3-1 and 3-1 victories at Old Trafford, and they can bring their hosts back down to earth.
Score prediction: Manchester United 1-2 Brighton
Brentford vs Liverpool (Saturday, 8pm)
Liverpool snapped their four-match losing streak with a comprehensive 5-1 Champions League win away to Eintracht Frankfurt but they face a tricky trip to Brentford on Saturday evening.
The Bees won 2-0 at West Ham on Monday and beat Manchester United 3-1 at home last month so a narrow Liverpool victory looks the most likely outcome.
Score prediction: Brentford 1-2 Liverpool
Bournemouth vs Nottingham Forest (Sunday, 2pm)
Bournemouth shared a thrilling 3-3 draw with fellow high flyers Crystal Palace last weekend but the Cherries should enjoy a regulation home win over Nottingham Forest on Sunday.
Forest look set for another defeat after a tumultuous few days in which they sacked manager Ange Postecoglou, appointed Sean Dyche and faced Porto in the Europa League on Thursday.
Score prediction: Bournemouth 2-0 Nottingham Forest
Arsenal vs Crystal Palace (Sunday, 2pm)
Arsenal's commanding start to the campaign continued with a 4-0 drubbing of Atletico Madrid in the Champions League and their defence should stand firm again up against Crystal Palace on Sunday.
The Gunners have won four of their last eight matches by a 2-0 scoreline and the Eagles suffered a rare defeat in their last away fixture at Everton.
Score prediction: Arsenal 2-0 Crystal Palace
Aston Villa vs Manchester City (Sunday, 2pm)
Manchester City's resurgence will be starting to concern their rivals and Pep Guardiola's men can grind out another three points at Aston Villa.
City have kept a clean sheet in seven of their eight wins this season and Villa have a quick turnaround after Thursday night's Europa League fixture against Go Ahead Eagles in the Netherlands.
Score prediction: Aston Villa 0-2 Manchester City
Wolves vs Burnley (Sunday, 2pm)
Burnley have claimed precious home wins over fellow promoted clubs Sunderland and Leeds this season but the Clarets have lost their four away fixtures at Tottenham, Manchester United, Manchester City and Aston Villa.
Wolves' recent performances have been better than their results and they may finally earn their first league win of the season.
Score prediction: Wolves 1-0 Burnley
Everton vs Tottenham (Sunday, 4.30pm)
Tottenham have hit a flat spot under Thomas Frank, letting slip a lead to lose at home to Aston Villa last weekend before a poor display in Wednesday's Champions League stalemate in Monaco.
Everton welcome back attacking inspiration Jack Grealish, who was ineligible to face his parent club Manchester City last time out, and they can extend the Spurs slump.
Score prediction: Everton 2 Tottenham 1.
