Arsenal have won 10 games in a row in all competitions
Promoted Sunderland occupy fourth after their 1-1 draw with Everton
Wolves are still winless and eight points behind 17th-placed Burnley
Gameweek 11 marks the final round of Premier League fixtures before yet another international break.
Arsenal remain six points clear at the top of the table ahead of Manchester City, while Sunderland continue to defy the odds in fourth.
At the wrong end of the table, Wolves are still searching for their first win and West Ham will look to move level on points with Burnley when the two sides meet on Saturday.
The game of the weekend sees Manchester City host Liverpool at the Etihad Stadium.
Tottenham vs Manchester United (Saturday, 12.30pm)
While Spurs have made a strong start to the season under Thomas Frank, their home form is still a worry.
Spurs have only won one game at home in the Premier League and they have only scored five goals in as many matches.
United have enjoyed a four-match unbeaten run and picked up 10 points during that time and they should frustrate the hosts, who played in Europe on Tuesday.
Score prediction: Tottenham 1-1 Manchester United
Everton vs Fulham (Saturday, 3pm)
Everton are winless in three games, but the arrival of Fulham at the Hill Dickinson Stadium should help them get back on track.
The Cottagers have yet to win away from home this season and they have only gained one point in five away ties.
Marco Silva's side have conceded 11 goals during that time and this looks to be a great chance for Everton to win the third game in six outings in their new home.
Score prediction: Everton 1-0 Fulham
West Ham vs Burnley (Saturday, 3pm)
West Ham can move level with Burnley with a win on Saturday and they have every chance of doing the business.
Nuno Espirito Santo's side beat Newcastle 3-1 last weekend to finally end their wait for a win under their new coach and they should have enough quality for a Burnley side that have only beaten Wolves on their travels this season.
Score prediction: West Ham 2-1 Burnley
Sunderland vs Arsenal (Saturday, 5.30pm)
Arsenal are searching for their 11th win in a row in all competitions and they will use their robust defence to get them over the line.
The Gunners have only conceded three goals all season and they face a Sunderland side who have registered a league-low 27 shots on target.
Score prediction: Sunderland 0-1 Arsenal
Chelsea vs Wolves (Saturday, 8pm)
Wolves have yet to appoint a new permanent boss after the sacking of Vitor Pereira and they should struggle on their trip to Stamford Bridge.
Chelsea are unbeaten in three, with one of those wins a 4-3 success against Wolves in the EFL Cup, and they should outclass a visiting side that have lost four on the spin.
Score prediction: Chelsea 3-1 Wolves
Aston Villa vs Bournemouth (Sunday, 2pm)
Aston Villa look back to their best after a sloppy start to the season and they should be able to squeeze their way past Bournemouth.
The Villans have won five in a row at home in all competitions and they can take care of a Cherries outfit that have won just once on the road all season.
Score prediction: Aston Villa 2-1 Bournemouth
Brentford vs Newcastle (Sunday, 2pm)
Newcastle have struggled for consistency due to their busy fixture schedule now they are back in Europe and they should be brought back down to earth after beating Athletic Bilbao.
The Magpies are winless away from St James' Park in five games and Brentford look well set for their fourth success in six at the Gtech Community Stadium.
Score prediction: Brentford 2-1 Newcastle
Crystal Palace vs Brighton (Sunday, 2pm)
Crystal Palace have won their last two games against rivals Brighton and they should be able to extend their overall winning run in all competitions to four matches.
The Eagles have beaten Liverpool, Brentford and AZ Alkmaar in recent weeks and they will fancy their chances of beating a Brighton side that have taken four points from a possible 15 away from home.
Score prediction: Crystal Palace 2-1 Brighton
Nottingham Forest vs Leeds (Sunday, 2pm)
A low-scoring game should be expected at the City Ground and the hosts may just edge it.
Forest have tightened up and improved since the arrival of Sean Dyche and they face a Leeds team that have only scored three goals away from Elland Road.
Score prediction: Nottingham Forest 1-0 Leeds
Manchester City vs Liverpool (Sunday, 4.30pm)
Liverpool have won back-to-back games against Aston Villa and Real Madrid and kept a clean sheet in both ties, but they have still got more to prove after losing six in their last nine.
Pep Guardiola's side have scored 10 goals in three games, so expect them to be firing on all cylinders in this clash of the weekend.
Score prediction: Manchester City 2-1 Liverpool
