Napoli sit 25th in the league phase and lost 3-0 at Juventus on Sunday
Chelsea are eighth in the table and have won four out of five under Liam Rosenior
Recommended bet: Chelsea to win
A win on matchday eight should be enough for Chelsea to qualify directly for the last 16 of the Champions League.
They face a Napoli side plagued by injuries and a coach, former Blues boss Antonio Conte, who has achieved great domestic success but has historically struggled to translate that into continental competition.
The Partenopei's 1-1 draw last week in Copenhagen means they are 25th in the league phase and in danger of failing to make the knockout rounds.
The latest Napoli vs Chelsea odds are available on LiveScore Bet
Team news
Former Chelsea forward Romelu Lukaku played his first minutes of the season against Juventus on Sunday, making it through the final 11 minutes in Turin.
However, injuries continue to force Conte's hand in recent weeks and he will again be without Andre-Frank Zambo Anguissa (thigh), Billy Gilmour (groin), Vanja Milinkovic-Savic (muscular), David Neres (ankle), Marco Politano (muscular) and Amir Rrahmani (muscular).
If available, Rrahmani would have been Napoli's only player in danger of missing their next European fixture by picking up a third yellow card, while Enzo Fernandez and Andrey Santos are both in that boat for Chelsea.
The Blues are without Tosin Adarabioyo (hamstring) and Dario Essugo (unspecified), while Filip Jorgensen (unspecified) and Cole Palmer (thigh) are doubts.
The stats
Napoli (W2, D2, L3) start the round 25th in the league phase and are one of five teams on eight points.
Chelsea (W4, D1, L2) are eighth in the standings but among eight teams on 13 points.
Of the 12 goals the Partenopei have conceded, nine have come after half-time.
Napoli have only won one of their last five Champions League games against sides from Europe's other top five leagues.
Four of Enzo Fernandez's last five goals have come away from Stamford Bridge.
The latest Napoli vs Chelsea odds are available on LiveScore Bet
Prediction
Napoli lost 3-0 at Juventus and are already nine points behind leaders Inter Milan, making it unlikely that they will be able to defend their Scudetto title.
Conte did not have European football to worry about last season, and the familiar issues of balancing domestic and continental football have again plagued him.
Opposite number Liam Rosenior is far earlier in his coaching journey but did a decent job of guiding Strasbourg through the Conference League before Christmas and won his first Champions League game in charge of Chelsea 1-0 against Pafos last week.
A trip to Napoli is a significant step up, but the Blues are good enough to handle the situation.
They outclassed Crystal Palace on Sunday, winning 3-1, with Joao Pedro's movement proving too much for the Eagles' back three.
Napoli line up in a similar shape and the Blues could claim their fifth win in six games under Rosenior.
Back Chelsea to win at 11/10 with LiveScore Bet
The latest Napoli vs Chelsea odds are available on LiveScore Bet
