Recently-crowned Serie A champions Inter are chasing their first domestic double since 2010.
Inter beat Lazio twice in Serie A this season, keeping clean sheets on each occasion (2-0, 3-0)
Recommended bet: Inter to win
Inter won the Serie A title at a canter this season, though the Nerazzurri have more silverware in their sights on Wednesday evening when they take on Lazio in the 2025/26 Coppa Italia Final at the Stadio Olimpico.
Lazio are facing their lowest league finish in seven years this term, though a first cup win since 2019 would be the perfect way to offset a disappointing campaign. Inter meanwhile, are targeting their first domestic double since the heady days of Jose Mourinho 16 years ago, and are odds-on favourites to triumph.
Christian Chivu’s side eased to a 3-0 win over Lazio in a one-sided cup final dress rehearsal on Saturday in the Italian capital and anything other than another Inter victory on Wednesday would be seen as a major upset.
The latest Lazio vs Inter odds are available on LiveScore Bet
Lazio vs Inter team news
With Wednesday’s Coppa Italia Final in mind, Lazio boss Maurizio Sarri rotated his usual lineup for Saturday’s Serie A encounter with Inter by resting Nuno Tavares, Gustav Isaksen, and Kenneth Taylor, while Mattia Zaccagni (adductor) was also absent, having picked up a minor injury in training.
Tavares, Isaksen and Taylor are expected to return to the fold in midweek, while skipper Zaccagni is also likely to be involved in some capacity.
Centre half Alessio Romagnoli was sent off against Inter on Saturday, though his suspension won’t carry over to the Coppa Italia and the defender is free to play.
Inter are likely to be without the services of influential attacking midfielder Hakan Çalhanoglu (calf), though their squad looks relatively injury-free elsewhere.
Federico Dimarco, Manuel Akanji, Denzel Dumfries and Yann Sommer were named as substitutes on Saturday, though that key quartet should be handed starting remits on Wednesday.
Lazio vs Inter stats
Inter have dominated recent meetings with Lazio and are unbeaten in nine previous meetings with the Biancocelesti in league and cup since August 2022.
Free-scoring Inter have scored 85 times in Serie A this season, which is a full 25 goals more than the next-highest scoring outfit in the division (Como – 60).
Inter have won on each of their last three trips to the Stadio Olimpico to face Lazio. The Nerazzurri beat Lazio both home and away in Serie A this season, running up an aggregate score of 5-0 in the process.
Lazio have failed to win 10 of their last 13 assignments at the Stadio Olimpico.
Inter striker Lautaro Martinez has scored eight goals in 15 previous appearances against Lazio. The 28-year-old scored home and away against Lazio in Serie A this season.
The latest Lazio vs Inter odds are available on LiveScore Bet
Lazio vs Inter Prediction
Lazio rested several of their stars in their 3-0 reverse at the Stadio Olimpico to Inter in Serie A on Saturday, but so did the champions, and the ease with which the Nerazzurri triumphed feels significant ahead of Wednesday’s Coppa Italia Final at the same venue.
The goal-scoring issues that have plagued Lazio for most of the campaign were laid bare again on Saturday. Their haul of just 39 goals in 36 league fixtures since August makes them the eighth lowest-scoring side in the division and Lazio look ill-equipped to match Inter’s firepower here.
Inter, who haven’t lost a domestic fixture since Christmas, are in fine form, winning six and drawing one of their last seven games, including Saturday’s success. Lazio meanwhile, have failed to win 10 of their last 13 matches at the Stadio Olimpico, so any talk about home advantage on Wednesday can be dismissed.
At 4/7 to win the Coppa Italia outright, Inter are easily the more backable side here, even at odds on, though bettors looking for a bigger price might consider backing Inter to win to nil at 13/8.
The Nerazzurri won each of their two Serie A meetings with Lazio without conceding and have beaten their rivals to nil in four of the clubs’ last five tussles overall.
H3 - Score Prediction – Lazio 0-2 Inter
H3 - More Blackburn vs Leicester predictions and recommended bets
Recommended bet | Stat |
Both teams to score - No – 19/20 | Lazio have failed to score in four of their last five meetings with Inter |
Over 1.5 Inter goals – 13/20 | Inter have scored over 1.5 goals in each of their last four encounters with Lazio. |
Lautaro Martinez to score anytime – 7/5 | Martinez scored home and away vs Lazio in Serie A this season and the Inter striker has notched eight times in 15 previous appearances against them overall. |
The latest Lazio vs Inter odds are available on LiveScore Bet
Lazio vs Inter will be played on Wednesday, 13th May 2026 at 20:00
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