Everton are bidding for a seventh win in 10 away games when they travel to Arsenal
Struggling Tottenham head to Liverpool, beaten in midweek by Galatasaray
Chelsea face Newcastle and Manchester United host Aston Villa in the battle for Europe
After a brutal week in Europe for English clubs, the Premier League resumes on Saturday with some vital fixtures at both ends of the table.
Leaders Arsenal host in-form Everton before second-placed Manchester City travel to West Ham, who will move out of the relegation zone if they avoid defeat.
The Hammers' survival rivals Tottenham head to Liverpool on Sunday and Brentford host bottom club Wolves on Monday evening.
Burnley vs Bournemouth (Saturday, 3pm)
Burnley lost 4-3 to Brentford in their last Premier League home game and they look set for another high-scoring defeat against Bournemouth. The Cherries have drawn their last three matches but can take out their frustration on the struggling Clarets.
Score prediction: Burnley 1 Bournemouth 3
Sunderland vs Brighton (Saturday, 3pm)
Sunderland won 1-0 at Leeds last week before suffering a shock 1-0 FA Cup defeat at Port Vale and goals could be scarce when they host Brighton.
December's reverse fixture ended 0-0 and another tight contest is expected at the Stadium of Light.
Score prediction: Sunderland 1 Brighton 1
Arsenal vs Everton (Saturday, 5.30pm)
Leaders Arsenal needed a late penalty to draw 1-1 at Bayer Leverkusen in the Champions League and they could drop points at home to Everton.
The Toffees have won six of their last nine away league fixtures and drew twice with the Gunners last season.
Score prediction: Arsenal 1 Everton 1
Chelsea vs Newcastle (Saturday, 5.30pm)
Chelsea beat Aston Villa 4-1 and Wrexham 4-2 before this week's 5-2 Champions League defeat at Paris Saint-Germain.
The goals should continue to flow when they host Newcastle, who drew 2-2 with the Blues just before Christmas but have struggled away from St James' Park.
Score prediction: Chelsea 3 Newcastle 2
West Ham vs Manchester City (Saturday, 8pm)
Manchester City suffered a 3-0 defeat against injury-hit Real Madrid on Wednesday and they may have to work hard to see off West Ham at the London Stadium.
The Hammers have boosted their survival chances in recent weeks but have won only one of their 15 matches against top-half teams.
Score prediction: West Ham 1 Manchester City 2
Crystal Palace vs Leeds (Sunday, 2pm)
Only three of Crystal Palace's 10 league wins this term have come at Selhurst Park, where they were held to a goalless draw by Larnaca in the Conference League on Thursday.
Leeds have lost their last two league fixtures by a 1-0 scoreline but they could nick a vital victory in south-east London.
Score prediction: Crystal Palace 0 Leeds 1
Manchester United vs Aston Villa (Sunday, 2pm)
Aston Villa continued their Europa League charge with a 1-0 win at Lille on Thursday but Unai Emery's men are in poor Premier League form.
Manchester United, beaten by 10-man Newcastle last week, can get back on track with their seventh win in nine matches under Michael Carrick.
Score prediction: Manchester United 2 Aston Villa 1
Nottingham Forest vs Fulham (Sunday, 2pm)
Nottingham Forest are under huge pressure in the relegation battle and their lack of cutting edge up front proved costly in Thursday's 1-0 Europa League loss to Midtjylland.
Sunday's visitors Fulham suffered a disappointing FA Cup exit against Southampton last weekend but they can pick up a point at the City Ground.
Score prediction: Nottingham Forest 1 Fulham 1
Liverpool vs Tottenham (Sunday, 4.30pm)
Tottenham were thrashed 5-2 by Atletico Madrid on Tuesday so the last thing they need is a trip to Anfield, where they have lost 4-3, 4-2, 4-0 and 5-1 on their last four visits.
Liverpool have also had problems away from home recently but they beat West Ham, one of Tottenham's survival rivals, 5-2 in their last league game at Anfield.
Score prediction: Liverpool 4 Tottenham 2
Brentford vs Wolves (Monday, 8pm)
Bottom club Wolves have produced a series of competitive displays recently, culminating in back-to-back home wins over Aston Villa and Liverpool.
However, they have scored only five times in 14 matches away from Molineux and Brentford can grind out a narrow win on Monday night.
Score prediction: Brentford 1 Wolves 0
