Champions Inter Milan kick off the new campaign when they host newly promoted Monza on Saturday
Last season's runners-up Napoli are on the road at Genoa in their opener later that evening
AC Milan begin Serie A life under Ruben Amorim with a trip to face Torino on Sunday night
Inter Milan cruised to the Serie A title last season and will get their defence under way on Saturday against newly promoted Monza. Fellow new boys Frosinone and Venezia face Juventus and Lecce respectively.
Udinese vs Como - Saturday August 22 (5.30pm)
Como have been a big revelation in Serie A in recent seasons and are showing no signs of slowing down under Cesc Fabregas, and they should start with a win against perennially mid-table Udinese.
Prediction: Udinese 1-2 Como (7/1 with LiveScore Bet)
Inter Milan vs Monza - Saturday August 22 (5.30pm)
Inter have torn up their back line since winning the title and both teams have scored in seven of their last 10 games. However, their attacking talent should see them cruise past newly-promoted Monza.
Prediction: Inter 3-1 Monza (19/2 with LiveScore Bet)
Parma vs Cagliari - Saturday August 22 (7.45pm)
Only Atalanta drew more games than Parma last season and they may have to settle for another stalemate with Cagliari, who have had plenty of turnover in their squad, in this curtain-raiser.
Prediction: Parma 1-1 Cagliari (23/5 with LiveScore Bet)
Genoa vs Napoli - Saturday August 22 (7.45pm)
Both teams have scored in the last six meetings between these two and that looks likely again, but take the visitors to edge it in their first league game under Massimiliano Allegri.
Prediction: Genoa 1-2 Napoli (15/2 with LiveScore Bet)
Venezia vs Lecce - Sunday August 23 (5.30pm)
Lecce narrowly stayed up last season and could suffer an opening-weekend defeat to Venezia, who have spent heavily over the summer.
Prediction: Venezia 1-0 Lecce (23/4 with LiveScore Bet)
Frosinone vs Juventus - Sunday August 23 (5.30pm)
Newly promoted Frosinone face a tough test against Juventus, who have won eight of the last nine head-to-heads. Their new-look attack without Dusan Vlahovic could hit the ground running.
Prediction: Frosinone 0-2 Juventus (27/5 with LiveScore Bet)
Torino vs Milan - Sunday August 23 (7.45pm)
Milan could come unstuck against a Torino side who were solid at home last season, and the stalemate is a runner in Ruben Amorim’s league debut.
Prediction: Torino 2-2 Milan (23/2 with LiveScore Bet)
Atalanta vs Sassuolo - Sunday August 23 (7.45pm)
Only the bottom four lost more games last season than Sassuolo’s 17 and they may open the new campaign with a defeat on their travels against an Atalanta side looking to bounce back from a disappointing campaign.
Prediction: Atalanta 2-1 Sassuolo (13/2 with LiveScore Bet)
Bologna vs Lazio - Monday August 24 (5.30pm)
Two of the three meetings between these two sides last season finished in a stalemate and that is a big contender again in this one. Take a low-scoring draw to land.
Prediction: Bologna 1-1 Lazio (24/5 with LiveScore Bet)
Roma vs Fiorentina - Monday August 24 (7.45pm)
Fiorentina had a frustrating campaign last time out and face a tough test in their opener against a Roma side who won the second-most games of any team in the league in 2025/26, 23. Take the hosts to edge this one.
Prediction: Roma 1-0 Fiorentina (11/2 with LiveScore Bet)
