Champions Arsenal kick off the weekend at home to Leeds United on Saturday
Struggling Manchester United host bottom club Tottenham
Sunday's big game sees Liverpool face league leaders Manchester City at Anfield
The Premier League returns after a three-week international break and we have all the key stats, team news and predictions for Gameweek 6.
Arsenal vs Leeds United – Saturday October 10 (12.30pm)
Key stats
Arsenal's Viktor Gyokeres scored in all four of Sweden's Nations League games
Arsenal beat Leeds 5-0 and 4-0 in last season's meetings
Leeds have lost only five of their last 30 Premier League matches
Anton Stach averages two fouls per 90 minutes for Leeds this term
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Team news
Arsenal midfielder Declan Rice should be fit after missing England's Nations League fixtures. Kai Havertz was injured while playing for Germany so striker Gyokeres is set for a first league start of the season.
Leeds will assess the fitness of winger Harry Wilson but his fellow Wales internationals Daniel James and Joe Rodon are out.
Need to know
Premier League champions Arsenal suffered a shock 3-0 defeat at Brighton before the international break and Mikel Arteta may be missing forward Havertz and winger Christos Tzolis for the clash with Leeds.
The Gunners won this fixture 5-0 last season but Leeds have improved significantly since then and could extend their unbeaten start with a draw in north London.
Score prediction: Arsenal 1-1 Leeds United (15/2 with LiveScore Bet)
Read our full Arsenal vs Leeds predictions for more stats and analysis.
Aston Villa vs Brentford – Saturday October 10 (3pm)
Key stats
Aston Villa's first three league and cup wins this season were by 3-2, 3-1 and 3-2 scorelines
Boubacar Kamara has committed nine fouls in five appearances for Villa
Brentford beat Villa 1-0 home and away last season
Bees midfielder Vitaly Janelt has been booked in three of his five league starts
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Team news
Aston Villa have doubts over Pau Torres, Matty Cash, Alysson, Leon Goretzka and Brian Madjo. Amadou Onana and Ian Maatsen are sidelined.
Brentford centre-back Jannik Schuster should start as Nathan Collins (calf) and Sepp van den Berg (groin) are doubts. Playmaker Mikkel Damsgaard (ankle) was injured on international duty with Denmark.
Need to know
Aston Villa claimed a much-needed 3-2 win at Tottenham in their last game but they remain a work in progress after a massive summer overhaul of the squad.
Brentford are far more settled and striker Igor Thiago, who was overlooked by Brazil in the international break, could help them to a third straight league win over Villa.
Score prediction: Aston Villa 1-2 Brentford (8/1 with LiveScore Bet)
Read our full Aston Villa vs Brentford predictions for more stats and analysis.
Chelsea vs Bournemouth – Saturday October 10 (3pm)
Key stats
Chelsea's matches against top-flight teams this season average 5.17 goals per game
Morgan Rogers claimed four assists in his last five outings for Chelsea
Bournemouth have drawn 11 of their last 17 league matches
Marcus Tavernier has had eight shots on target in five league games this season
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Team news
Chelsea are missing striker Joao Pedro but should welcome back key men Cole Palmer, Reece James and Moises Caicedo.
Bournemouth's England midfielder Alex Scott has been ruled out for a month but David Brooks is back in full training.
Need to know
Chelsea's last three home games were a 4-3 win over Brighton, a 6-3 EFL Cup victory over Leeds and a 2-2 draw with promoted Hull.
Away defeats to Arsenal and Brentford dented their record under Xabi Alonso but the Blues should claim another entertaining win over Bournemouth, who are missing star midfielder Alex Scott and striker Eli Junior Kroupi.
Score prediction: Chelsea 3-1 Bournemouth (19/2 with LiveScore Bet)
Read our full Chelsea vs Bournemouth predictions for more stats and analysis.
Ipswich Town vs Fulham – Saturday October 10 (3pm)
Key stats
Ipswich conceded six goals in the first 20 minutes of their last four matches
Zian Flemming has had three shots on target in 60 minutes of playing time for Ipswich
Fulham won only four of their 21 away games since the start of last season
The Cottagers failed to have a shot on target in August's 1-0 defeat at Sunderland
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Team news
Ipswich winger Abdul Fatawu is suspended following his red card at Everton. Jaden Philogene is a natural replacement on the right flank.
Fulham's only confirmed absentee is Tom Cairney although full-back Kenny Tete faces a fitness test.
Need to know
Fulham conceded an 89th-minute equaliser against Manchester United last time out, denying them a first league win under Alvaro Arbeloa.
The Cottagers face the three promoted clubs in their next three games - a crucial run of fixtures for Arbeloa - but they are poor travellers and should be opposed at Ipswich.
Score prediction: Ipswich Town 2-1 Fulham (8/1 with LiveScore Bet)
Read our full Ipswich vs Fulham predictions for more stats and analysis.
Sunderland vs Brighton – Saturday October 10 (3pm)
Key stats
Sunderland's first four home matches this season were goalless at half-time
The Black Cats' three wins this term were all by a 1-0 margin
Brighton have scored 23 goals in their last seven matches
Pascal Gross contributed four goals and three assists in his last five games for Brighton
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Team news
Sunderland will be without centre-back Dan Ballard and striker Brian Brobbey, who suffered hamstring injuries on international duty.
Brighton captain Lewis Dunk (neck) returns to the defence but there are doubts over Pascal Struijk, Yasin Ayari, Jack Hinshelwood and Yankuba Minteh. Winger Kaoru Mitoma is injured.
Need to know
Expect a clash of styles at the Stadium of Light as free-scoring Brighton travel to Sunderland, who have won three of their first four home fixtures to nil this season.
Two of those wins came against Hull in the EFL Cup and AZ Alkmaar but the Black Cats suffered some damaging injuries over the international break and could be outclassed by in-form Brighton.
Score prediction: Sunderland 0-2 Brighton (19/2 with LiveScore Bet)
Read our full Sunderland vs Brighton predictions for more stats and analysis.
Manchester United vs Tottenham – Saturday October 10 (5.30pm)
Key stats
Manchester United have won only two of their seven league and cup games this season
Bruno Fernandes has had 19 shots in five league starts
Tottenham failed to score in four of their five matches this term
Savio averages 1.1 shots on target per 90 minutes in his Premier League career
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Team news
Manchester United's summer signing Carlos Baleba is pushing for a debut but striker Benjamin Sesko and full-back Patrick Dorgu are expected to miss out.
Tottenham's Pedro Porro, Dejan Kulusevski, Xavi Simons, Wilson Odobert and Mykhaylo Mudryk are sidelined. Archie Gray could deputise for Porro at right-back.
Need to know
Manchester United manager Michael Carrick and Tottenham's Roberto De Zerbi are both feeling the heat after poor starts to the season.
Spurs are bottom of the table but they have lost only one of their last nine meetings with United and could upset the odds against their struggling hosts at Old Trafford.
Score prediction: Manchester United 1-2 Tottenham (11/1 with LiveScore Bet)
Read our full Manchester United vs Tottenham predictions for more stats and analysis.
Crystal Palace vs Nottingham Forest – Sunday October 11 (2pm)
Key stats
Crystal Palace have won only four of their last 21 home league games
Five of the last seven meetings between these clubs ended 1-1
All four of Nottingham Forest's league goals have come away from home this season
Forest's Dan Ndoye has scored in six of his last 12 internationals for Switzerland
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Team news
Crystal Palace centre-back Axel Disasi is still suspended but goalkeeper Dean Henderson and forwards Ismaila Sarr and Jean-Philippe Mateta could return to the squad after injuries.
Nottingham Forest's squad is in good health although defenders Nikola Milenkovic and Nicolo Savona will be assessed.
Need to know
Oliver Glasner swapped Crystal Palace for Nottingham Forest in the summer and it will be interesting to see what kind of reception he gets at Selhurst Park.
Forest failed to score in four home games under Glasner but they have been more fluent on the road, drawing 2-2 at Liverpool before a 2-1 win at Aston Villa.
Palace hope to have ace attackers Ismaila Sarr and Jean-Philippe Mateta available again and their four home league and cup games this term produced 17 goals.
Score prediction: Crystal Palace 2-2 Nottingham Forest (21/2 with LiveScore Bet)
Read our full Crystal Palace vs Nottingham Forest predictions for more stats and analysis.
Hull City vs Everton – Sunday October 11 (2pm)
Key stats
Hull's Mohamed Belloumi has scored two and set up two of Hull's six goals
The Tigers have kept three clean sheets in five Premier League games
Everton have drawn three of their last four league matches
The Toffees are on a seven-match winless run away from home in the top flight
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Team news
Hull's Nobel Mendy and Hidemasa Morita should be passed fit but Brooke Norton-Cuffy is a doubt. Eliot Matazo, Ilyas Ansah, Darko Gyabi, Jack Butland and Charlie Hughes are injured.
Everton hope to have Christian Norgaard available for the first time since his summer move from Arsenal. Merlin Rohl and Vitalii Mykolenko face fitness tests.
Need to know
Relegation favourites Hull City have made a great start to the campaign, beating Manchester United and Coventry and drawing with Aston Villa and Chelsea.
The Tigers, last season's Championship play-off winners, look set for another tight contest against Everton, who had three draws on the spin before a tense 1-0 home win over 10-man Ipswich.
Score prediction: Hull City 1-1 Everton (5/1 with LiveScore Bet)
Read our full Hull vs Everton predictions for more stats and analysis.
Liverpool vs Manchester City – Sunday October 11 (4.30pm)
Key stats
Milos Kerkez was booked in five of his last 10 games for Liverpool and Hungary
Liverpool have kept three straight clean sheets in the Premier League
Manchester City won all three of last season's meetings by an aggregate score of 9-1
City have won their last seven games in all competitions
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Team news
Liverpool have major concerns over forwards Alexander Isak and Cody Gakpo and centre-back Jeremy Jacquet. Hugo Ekitike and Conor Bradley remain sidelined.
Manchester City expect striker Erling Haaland to overcome muscle fatigue. Phil Foden is suspended and Antoine Semenyo is a doubt so Iliman Ndiaye and Jeremy Doku may start on the flanks.
Need to know
The game of the weekend takes place at Anfield, where Manchester City are in action for the first time since being found guilty of breaching the Premier League's financial regulations.
City beat Liverpool 3-0, 2-1 and 4-0 last term and their players could respond positively against the Reds, who may be missing in-form forwards Alexander Isak and Cody Gakpo.
Score prediction: Liverpool 0-1 Manchester City (19/2 with LiveScore Bet)
Read our full Liverpool vs Manchester City predictions for more stats and analysis.
Coventry City vs Newcastle United – Monday October 12 (8pm)
Key stats
Coventry lost their first four league matches to nil this season
Frank Onyeka has been booked in 21 of his last 58 league starts
Newcastle have lost seven of their last nine away games in all competitions
Joe Willock averages 3.1 shots per 90 minutes in the league this season
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Team news
Coventry's Brandon Thomas-Asante should start up front as Haji Wright is injured and Taiwo Awoniyi is suspended.
Newcastle midfielders Joelinton, Lewis Miley and Nico Gonzalez may return but Tino Livramento, Amar Dedic, Anthony Elanga and William Osula are sidelined.
Need to know
Coventry celebrated their first Premier League win since 2001 as Jay Dasilva scored the only goal of the game at Nottingham Forest just before the international break.
Frank Lampard's men had lost their first four matches to nil but they should create plenty of chances against injury-hit Newcastle, who were thumped 4-1 by Leeds on their last away trip.
Score prediction: Coventry City 2-1 Newcastle United (19/2 with LiveScore Bet)
Read our full Coventry vs Newcastle predictions for more stats and analysis.
