Southampton have lost just one of their last seven at home
Sheff Utd have nine defeats in 14 away games in the league
Recommended bet: Southampton to win
Southampton and Sheff Utd were rated among the promotion contenders before the season began , ut both clubs find themselves stranded in mid-table.
Saints are 10 points behind Preston in the final play-off place and just six clear of the bottom three, while the Blades are a point further back.
A late surge towards the top six is not completely off the table for either side, but they would need to hit form and both clubs have seen recent revivals halted.
Southampton are on a seven-game winless run in the league, while the visitors have three defeats in their last six league games and were eliminated from the FA Cup in the third round by League One's Mansfield Town earlier this month.
The latest Southampton vs Sheff Utd odds are available on LiveScore Bet
Team news
Mads Roerslev, Shea Charles and Samuel Edozie are expected to miss out once again for Southampton due to ongoing injury issues.
Japhet Tanganga and Djibril Soumare were both sent off for the Blades in their 1-0 loss at Charlton over the weekend, so are suspended for Wednesday's game.
Jairo Riedewald missed the defeat at The Valley but could come back into contention.
The stats
United have four defeats in their last seven games across all competitions and the Blades have lost three of their last four away games.
Southampton have 20 points to show from 13 home games and all three of their home league losses have come against teams currently in the top seven.
Saints have won five of the last six meetings between these sides across all competitions, with one draw.
The latest Southampton vs Sheff Utd odds are available on LiveScore Bet
Prediction
Both sides could both do with a boost as their respective promotion hopes appear to be slipping away, but home advantage gives Saints a clear edge ahead of their meeting on Wednesday.
The Blades had a great run from the end of November as they picked up 22 points in a 10-game spell, but that momentum has been lost after back-to-back losses, including that FA Cup defeat to Mansfield.
United have been fairly poor on their travels all season with nine defeats in 14 Championship trips, although they have won the other five games.
Saints may be out of sorts, but their home form has been generally good. They have only lost three times at home in the league this season and all of those losses have come against play-off contenders.
Southampton won the reverse fixture 2-1 earlier in the season and they could be coming up against United at the right time.
Tanganga's suspension leaves a big void in the visiting defence and they arrive out of form, so Saints look good value to end their winless streak against a Blades outfit who have struggled on the road all season.
