Manchester City and Chelsea aim to overturn three-goal deficits in Tuesday's home legs against Real Madrid and PSG
Premier League leaders Arsenal host Bayer Leverkusen after last week's 1-1 draw in Germany
Newcastle travel to Barcelona on Wednesday, having conceded an injury-time equaliser in the first leg at St James' Park
After a dramatic round of Champions League last-16 first legs, this season's quarter-final line-up will be decided in Tuesday and Wednesday's second legs.
None of the six English clubs managed to claim a lead last week. Trophy favourites Arsenal, level at 1-1 with Bayer Leverkusen, and Liverpool, who lost 1-0 away to Galatasaray, look the most likely Premier League teams to reach the last eight.
Sporting vs Bodo/Glimt (Tuesday, 5.45pm)
Bodo/Glimt's amazing Champions League winning streak continued with a 3-0 home victory over Sporting, who will have to take risks if they are to pull off a comeback.
The Lisbon giants are formidable on their own patch but Bodo won 2-1 at Atletico Madrid and Inter Milan on their last two away trips.
Score prediction: Sporting 2 Bodo/Glimt 2
Arsenal vs Bayer Leverkusen (Tuesday, 8pm)
A late Kai Havertz penalty earned Arsenal a 1-1 draw away to Bayer Leverkusen and Saturday's 2-0 Premier League win over Everton was goalless until the 89th minute.
The Gunners won all eight of their league-phase matches in the Champions League but it could be another tense night at the Emirates Stadium.
Score prediction: Arsenal 2 Bayer Leverkusen 1
Chelsea vs PSG (Tuesday, 8pm)
Champions League holders PSG produced a clinical performance to beat Chelsea 5-2 in Paris and the return leg should also produce plenty of goals.
PSG won away legs at Liverpool and Arsenal en route to glory last season and they can end Chelsea's perfect home record in this term's competition.
Score prediction: Chelsea 2 PSG 3
Manchester City vs Real Madrid (Tuesday, 8pm)
Manchester City suffered a hugely disappointing 3-0 defeat against a depleted Real Madrid side last week before being held to a 1-1 league draw at West Ham on Saturday night.
City won 2-1 at the Bernabeu in December's league-phase fixture and they are unlikely to blow away Real in Manchester.
Score prediction: Manchester City 2 Real Madrid 1
Barcelona vs Newcastle (Wednesday, 5.45pm)
Barcelona needed an injury-time Lamine Yamal penalty to claim a 1-1 draw at Newcastle, who went on to beat Chelsea 1-0 at Stamford Bridge at the weekend.
However, the Magpies face a daunting second leg at Camp Nou, where Barca have won 18 of their 19 games in all competitions this season.
Score prediction: Barcelona 3 Newcastle 1
Bayern Munich vs Atalanta (Wednesday, 8pm)
Several of the main Champions League contenders fluffed their lines last week but Bayern Munich crushed hosts Atalanta 6-1 in Bergamo.
The Italians have won only one of their last eight away matches and another heavy defeat is looming, even if Bayern boss Vincent Kompany rests some of his star players.
Score prediction: Bayern Munich 4 Atalanta 1
Liverpool vs Galatasaray (Wednesday, 8pm)
Galatasaray beat Liverpool 1-0 at home in the league phase and the last-16 first leg but the Reds should overturn that deficit at Anfield.
Arne Slot's men kept a clean sheet in each of their last four Champions League victories while Galatasaray failed to score in 90 minutes in their last three away fixtures at Monaco, Manchester City and Juventus.
Score prediction: Liverpool 2 Galatasaray 0
Tottenham vs Atletico Madrid (Wednesday, 8pm)
After a 5-2 first-leg rout by Atletico Madrid, Tottenham restored some pride thanks to Richarlison's late equaliser against Liverpool in the Premier League.
Atletico are far less convincing away from home, conceding 13 goals on their five Champions League trips this season, so a high-scoring draw could be on the cards in the second leg.
Score prediction: Tottenham 2 Atletico Madrid 2
