Arsenal bid for a ninth win in nine Champions League games at Bayer Leverkusen on Wednesday
Tottenham and Chelsea face tough last-16 first-leg trips to Atletico Madrid and PSG
Real Madrid set to be without Kylian Mbappe and Jude Bellingham for Wednesday's clash with Man City
The Champions League returns this week and there are eight cracking last-16 first legs on Tuesday and Wednesday.
Newcastle's home fixture against Barcelona is one of Tuesday's highlights before Arsenal, who topped the league-phase standings, travel to Bayer Leverkusen and Real Madrid host Manchester City on Wednesday.
Galatasaray vs Liverpool (Tuesday, 5.45pm)
Galatasaray beat Liverpool 1-0 in the league phase thanks to an early Victor Osimhen penalty and another tight contest is expected on Tuesday.
The hosts have lost only one of their 20 home matches in all competitions this season and they can frustrate Arne Slot's Reds.
Score prediction: Galatasaray 1-1 Liverpool
Atalanta vs Bayern Munich (Tuesday, 8pm)
Atalanta overturned a 2-0 first-leg deficit to knock out Borussia Dortmund in the play-off round but they face a far tougher test against another German side in the last 16.
Bayern Munich won seven of their eight league-phase matches and stretched their lead in the Bundesliga to 11 points thanks to Saturday's 3-2 win in Dortmund.
Score prediction: Atalanta 1-2 Bayern Munich
Atletico Madrid vs Tottenham (Tuesday, 8pm)
Tottenham made the most of a soft set of fixtures to finish fourth in the Champions League standings but Igor Tudor's men may be brought down to earth by Atletico Madrid.
The hosts beat Club Brugge 4-1 in the home leg of their play-off tie and won 4-2 against Espanyol and 3-2 against Real Sociedad in their last two La Liga home fixtures.
Score prediction: Atletico Madrid 3-1 Tottenham
Newcastle vs Barcelona (Tuesday, 8pm)
Marcus Rashford's brace gave Barcelona a 2-1 win at Newcastle on matchday one of the league phase and the Catalan giants should storm St James' Park again.
Eddie Howe's Magpies have been conceding bundles of goals at home recently, losing 3-2 to Brentford and Everton in the Premier League and 3-1 to Manchester City in Saturday's FA Cup fifth-round clash.
Score prediction: Newcastle 1-3 Barcelona
Bayer Leverkusen vs Arsenal (Wednesday, 5.45pm)
The Champions League draw has opened up nicely for Arsenal and they can grind out a narrow first-leg advantage against Bayer Leverkusen in Germany.
Leverkusen are unlikely to roll over against Mikel Arteta's men. They restricted play-off opponents Olympiakos to just two shots on target in 180 minutes and Arsenal's last Premier League result was a hard-fought 1-0 win at Brighton.
Score prediction: Bayer Leverkusen 0-1 Arsenal
Bodo/Glimt vs Sporting (Wednesday, 8pm)
Bodo/Glimt have produced some stunning performances in Europe this season, beating Manchester City 3-1, Atletico Madrid 2-1 and Inter 3-1 and 2-1 in their last four games.
They can rack up another memorable victory on their artificial pitch against a Sporting side who picked up only four of their 16 league-phase points on the road.
Score prediction: Bodo/Glimt 2-1 Sporting
PSG vs Chelsea (Wednesday, 8pm)
Chelsea were taken to extra-time by Wrexham in the FA Cup on Saturday but they could claim a first-leg draw against injury-hit Champions League holders Paris Saint-Germain.
The French champions lost 3-1 at home to Monaco in Ligue 1 last week, having squeezed past the same opponents 5-4 on aggregate in the play-off round.
Score prediction: PSG 2-2 Chelsea
Real Madrid vs Manchester City (Wednesday, 8pm)
Manchester City won 2-1 at Real Madrid in December's league-phase clash at the Bernabeu, where the hosts scored with their only shot on target.
Real have lost two of their last three matches in LaLiga and, missing injured stars Kylian Mbappe, Jude Bellingham and Rodrygo, they look set for a tough night against in-form City.
Score prediction: Real Madrid 0-2 Manchester City.
