
Barcelona have won 13 of their last 14 games
Barcelona have won five of the last seven head-to-heads
Recommended bet: Barcelona to win & both teams to score
Barcelona have been the dominant force in women's European football in recent years, winning three of the last five Women's Champions League titles.
They beat Chelsea en route to the final last year and the duo do battle again in the new-look league phase.
The hosts have had a solid start to their European campaign, winning two and drawing one of their three games, but this is undoubtedly their most formidable challenge to date.
Team news
Chelsea are suffering with a number of injury issues with Hannah Hampton, Guro Reiten, Kadeisha Buchanan, Mayra Ramirez and Brooke Aspin all absent.
It also remains to be seen if Lauren James and Sam Kerr will be fit enough to start.
Barcelona will be without Salma Paralluelo and Patri Guijarro through injury, while Esmee Brugts is a doubt.
The latest Chelsea Women vs Barcelona Women odds are available on LiveScore Bet
The stats
Barcelona won 8-2 on aggregate when these two teams met in the semi-final of this competition last season, winning both games by a 4-1 scoreline.
Chelsea have failed to win four of their last eight matches in all competitions.
Barca have scored 14 and conceded once in their three European matches this term.
Barcelona have reached the final of the last five Women's Champions Leagues, winning three of those.
The latest Chelsea Women vs Barcelona Women odds are available on LiveScore Bet
Prediction
Chelsea and Barcelona have become somewhat familiar foes.
This will be their fourth successive season in which they have met in the Women's Champions League, although the previous three were all at the semi-final stage.
Barca have dominated that head-to-head, progressing from all three ties, and have won five of the last seven meetings between the two teams.
The visitors look better than ever this season, as evidenced by the fact that they beat rivals Real Madrid 4-0 at the weekend.
Chelsea, on the other hand, have drawn two of their last three games and are struggling with injuries to key players.
Barcelona were 4-1 winners in both matches when these two teams met last season and they look likely to win another contest in which both teams find the net.
The visitors class edge should tell and they can outscore the home side.
Back over Barcelona to win & both teams to score at 7/4 with LiveScore Bet
The latest Chelsea Women vs Barcelona Women odds are available on LiveScore Bet