West London rivals Brentford and Chelsea kick off the action on Friday night
Tottenham and Aston Villa are chasing a first league win of 2026-27 when they meet on Saturday
Liverpool boss Andoni Iraola takes on his former club Bournemouth on Sunday
The fifth round of 2026-27 Premier League fixtures starts on Friday when Xabi Alonso's Chelsea make the short trip to Brentford.
Winless Tottenham and Aston Villa meet in north London on Saturday before champions Arsenal head to Brighton and struggling Manchester United face Fulham at Craven Cottage.
Brentford vs Chelsea - Friday September 18 (8pm)
Chelsea have kept only one clean sheet in their last 26 Premier League matches and Xabi Alonso's men could come unstuck on their trip to unbeaten Brentford.
Score prediction: Brentford 2-1 Chelsea (17/2 with LiveScore Bet)
Tottenham vs Aston Villa - Saturday September 19 (12.30pm)
Tottenham and Aston Villa have scored only one goal between them in eight Premier League matches this season and the winless rivals may have to settle for a point apiece.
Score prediction: Tottenham 1-1 Aston Villa (11/2 with LiveScore Bet)
Brighton vs Arsenal - Saturday September 19 (3pm)
Brighton have scored bundles of goals this term but their fun may come to an end against champions Arsenal.
The Gunners won this fixture 1-0 in 2025-26 and beat Aston Villa 1-0, Napoli 1-0 and Sunderland 2-0 in their first three away games of the new season.
Score prediction: Brighton 0-2 Arsenal (7/1 with LiveScore Bet)
Everton vs Ipswich - Saturday September 19 (3pm)
Ipswich won 3-2 at 10-man Crystal Palace last weekend and both teams have scored in five of their six games this season.
However, Everton are a consistent side and they can nick an important win at the Hill Dickinson Stadium.
Score prediction: Everton 2-1 Ipswich (13/2 with LiveScore Bet)
Newcastle vs Hull - Saturday September 19 (3pm)
Promoted Hull's dream start to the season continued with an excellent 2-2 draw at Chelsea last weekend and they can pick up another point at Newcastle, who were outclassed by Leeds on Monday.
Score prediction: Newcastle 1-1 Hull (7/1 with LiveScore Bet)
Nottingham Forest vs Coventry - Saturday September 19 (5.30pm)
Last season's Championship winners Coventry have lost their first four Premier League games to nil and may struggle to land a blow on Forest, who have taken five points from their last three matches against Liverpool, Tottenham and Aston Villa.
Score prediction: Nottingham Forest 2-0 Coventry (13/2 with LiveScore Bet)
Bournemouth vs Liverpool - Sunday September 20 (2pm)
Bournemouth were draw specialists last season under Andoni Iraola, whose first four league results as Liverpool manager include 2-2 draws against Newcastle and Nottingham Forest.
Score prediction: Bournemouth 2-2 Liverpool (9/1 with LiveScore Bet)
Leeds vs Crystal Palace - Sunday September 20 (2pm)
Leeds thrashed Newcastle 4-1 at Elland Road on Monday and should be too slick for Crystal Palace, who are missing several key players and have a quick turnaround from Thursday's Europa League opener against Lech Poznan.
Score prediction: Leeds 3-1 Crystal Palace (21/2 with LiveScore Bet)
Manchester City vs Sunderland - Sunday September 20 (2pm)
Manchester City have shown their gritty side in recent weeks, winning 1-0 against Coventry and 2-0 at Porto before beating Manchester United 1-0 at Old Trafford despite Phil Foden's early red card.
Sunderland are always obdurate opponents but City should grind out a fifth win in five league games under Enzo Maresca.
Score prediction: Manchester City 1-0 Sunderland (13/2 with LiveScore Bet)
Fulham vs Manchester United - Sunday September 20 (4.30pm)
Manchester United are under pressure after last weekend's derby defeat to City and Wednesday's 3-2 Carabao Cup loss to Brighton.
They could be vulnerable at Fulham, who are strong at home and have shown signs of improvement in recent games under Alvaro Arbeloa.
Score prediction: Fulham 2-1 Manchester United (19/2 with LiveScore Bet)
