Manchester City are hot favourites to claim a home win over Ipswich on Saturday
Under-pressure Manchester United manager Michael Carrick faces a tough trip to Leeds
Coventry bid for a third straight victory when they travel to winless Tottenham on Monday
After a busy week of European football, the Premier League returns with some fascinating fixtures and we have key stats, team news and predictions for every game.
Everton vs Chelsea - Saturday, October 17 (12.30pm)
Key stats
Everton have drawn four of their first six Premier League games
Toffees striker Thierno Barry has fired 20 shots in his last five league starts
Chelsea's matches against top-flight teams this term average 5.29 goals per game
Morgan Rogers contributed four goals and five assists in his last 10 outings for Chelsea and England
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Team news
Everton's only injury concern is over Vitalii Mykolenko. Jarrad Branthwaite could fill in at left-back again if Mykolenko is not fit.
Chelsea's Reece James is out for three months after knee surgery. Jordan Henderson should keep his place in midfield.
Need to know
Chelsea's inconsistency is demonstrated by their last two Premier League results as they followed up a 3-0 loss at Brentford by thrashing Bournemouth 5-1.
There have been 28 goals in the Blues' first six league games under Xabi Alonso and another exciting contest looks likely at unbeaten Everton, whose in-form striker Thierno Barry can add to his goal tally.
Score prediction: Everton 2-2 Chelsea (19/2 with LiveScore Bet)
Read our full Everton vs Chelsea predictions for more stats and analysis
Brentford vs Liverpool - Saturday, October 17 (3pm)
Key stats
Both teams scored in six of Brentford's last seven games
Vitaly Janelt has been booked in four of his six league appearances
Florian Wirtz has committed 11 fouls in six top-flight games
Liverpool have conceded only three first-half goals in nine matches
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Team news
Brentford will assess the fitness of top scorer Kevin Schade and defenders Nathan Collins and Jannik Schuster.
Liverpool midfielder Ryan Gravenberch is suspended. Cody Gakpo, Alexander Isak and Dominik Szoboszlai face fitness tests.
Need to know
Brentford's impressive rise under Keith Andrews is reflected by the fact that they are clear favourites to beat injury-hit Liverpool.
The Reds hammered LASK 6-3 in the Champions League but crumbled to a 3-0 home defeat against Manchester City last weekend and are missing suspended midfielder Ryan Gravenberch, who was sent off in the City game.
Score prediction: Brentford 2-1 Liverpool (15/2 with LiveScore Bet)
Read our full Brentford vs Liverpool predictions for more stats and analysis
Fulham vs Hull - Saturday, October 17 (3pm)
Key stats
Both of Fulham's home defeats this season were by a 3-2 scoreline
Gonzalo Garcia averages three shots per 90 minutes in the league for Fulham
Hull striker Oli McBurnie has been booked in four of his last five starts
Mohamed Belloumi has racked up three goals and two assists in six appearances
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Team news
Fulham's Antonee Robinson and Tom Cairney could return, leaving Hugo Larsen (groin) as the only doubt.
Hull's lengthy injury list includes Mohamed-Ali Cho, Lucas Gourna-Douath, Nobel Mendy, Charlie Hughes, Darko Gyabi, Ilyas Ansah, Matt Targett and Eliot Matazo.
Need to know
Late goals hurt bottom club Fulham in their last two games as they drew 1-1 at home to Manchester United and lost 2-1 at Ipswich.
Manager Alvaro Arbeloa is under pressure going into Saturday's game against promoted Hull but Fulham tend to do their best work at home and the Tigers are dealing with an injury crisis.
Score prediction: Fulham 2-1 Hull (13/2 with LiveScore Bet)
Read our full Fulham vs Hull predictions for more stats and analysis
Manchester City vs Ipswich - Saturday, October 17 (3pm)
Key stats
Manchester City have scored 11 of their 16 league goals in the second half of matches
Rayan Cherki produced a goal or an assist in six of his last eight games for City and France
Both teams scored in six of Ipswich's eight games
Ipswich's Sasa Lukic averages 2.6 fouls per 90 minutes in the league
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Team news
Manchester City should have a fully-fit squad with Phil Foden available after suspension.
Ipswich are also in good shape as winger Abdul Fatawu served his one-match ban last weekend.
Need to know
Manchester City did not have long to bask in their 3-0 win at Anfield as they were beaten 4-2 by European champions Paris Saint-Germain on Wednesday.
Saturday's visitors Ipswich do not have the same attacking quality as PSG but they have won three of their first six league matches and can get on the scoresheet against City.
Score prediction: Manchester City 4-1 Ipswich Town (11/1 with LiveScore Bet)
Read our full Manchester City vs Ipswich predictions for more stats and analysis
Newcastle vs Aston Villa - Saturday, October 17 (5.30pm)
Key stats
Joelinton has been booked 21 times in 53 league starts since the beginning of the 2024-25 season
Newcastle's last two defeats were both by a 4-1 scoreline
Aston Villa won their last three away games by 3-2, 3-1 and 3-2 scorelines
Villa's Nicolas Jackson has scored five goals in his last six matches
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Team news
Newcastle's Joelinton should start in midfield and Bazoumana Traore has overcome an ankle injury but Anthony Elanga, Tino Livramento and Jacob Ramsey are sidelined.
Aaron Wan-Bissaka may start at left-back for Aston Villa as Matteo Ruggeri and Ian Maatsen are injured.
Need to know
Aston Villa's forwards have clicked into gear, winning 3-2 at Tottenham, drawing 2-2 with Brentford and hammering Fenerbahce 6-0 in their last three matches.
Villa should be confident of troubling a Newcastle side whose last three results include 4-1 defeats against Leeds and Coventry.
Score prediction: Newcastle 1-3 Aston Villa (16/1 with LiveScore Bet)
Read our full Newcastle vs Aston Villa predictions for more stats and analysis
Bournemouth vs Sunderland - Sunday, October 18 (2pm)
Key stats
Both teams scored in five of Bournemouth's six league matches
Evanilson has claimed three assists in six top-flight starts this season
Sunderland lost four of their first six games in 2026-27
Malick Fofana has had seven shots in 173 minutes of league action for Lyon and Sunderland
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Team news
Bournemouth are missing the injured Alex Scott, Eli Junior Kroupi and Julian Araujo. Centre-back Veljko Milosavljevic (knee) is closing in on a return.
Sunderland defenders Dan Ballard and Thomas Meunier are out but Dutch striker Brian Brobbey (hamstring) is back.
Need to know
Bournemouth and Sunderland have made perfect starts to their Europa League campaigns although their Premier League results have been less impressive.
The Cherries lost 5-1 at Chelsea last weekend but they can break their league duck under Marco Rose with a narrow win over the Black Cats.
Score prediction: Bournemouth 1-0 Sunderland (7/1 with LiveScore Bet)
Read our full Bournemouth vs Sunderland predictions for more stats and analysis
Brighton vs Crystal Palace - Sunday, October 18 (2pm)
Key stats
Six of the last 14 meetings between these clubs ended 1-1
Brighton's Diego Gomez has had six shots on target in six league starts
Six of Crystal Palace's last eight matches featured over 3.5 goals
Jorgen Strand Larsen had nine shots on target in his last six Palace appearances
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Team news
Brighton winger Kaoru Mitoma is sidelined and there are fitness doubts over Mats Wieffer, Yankuba Minteh and Pascal Struijk, whose red card at Sunderland was overturned on appeal.
Crystal Palace hope to welcome back Jean-Philippe Mateta, Dean Henderson, Ben Chilwell and Takehiro Tomiyasu but centre-back Axel Disasi is suspended.
Need to know
After kicking off their Conference League campaign with a 4-0 rout of Kauno Zalgiris, Brighton should expect more resistance from rivals Crystal Palace.
The Seagulls have won their last five games by an aggregate score of 17-2 but lost three of their last four meetings with the Eagles.
Score prediction: Brighton 1-1 Crystal Palace (7/1 with LiveScore Bet)
Read our full Brighton vs Crystal Palace predictions for more stats and analysis
Leeds vs Manchester United - Sunday, October 18 (2pm)
Key stats
Leeds have lost only five of their last 31 Premier League matches
Defender James Justin has had seven shots in his last five league games
Manchester United's only clean sheet in nine matches came against Sabah in the Champions League
Diogo Dalot averages 1.7 fouls per 90 minutes in the league
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Team news
Leeds are missing Joe Rodon and Mateo Joseph but winger Dan James could face his former club.
Manchester United have doubts over Luke Shaw and Kobbie Mainoo. Striker Benjamin Sesko is unlikely to be fit but centre-back Lisandro Martinez is available.
Need to know
Leeds are eager to deepen the gloom surrounding Manchester United, whose defender Lisandro Martinez criticised the running of the club following Tuesday's 2-0 Champions League defeat at Atletico Madrid.
Martinez and his fellow defenders can expect a difficult trip to Elland Road, where Leeds have won five and drawn three of their last eight matches.
Score prediction: Leeds 2-0 Manchester United (11/1 with LiveScore Bet)
Read our full Leeds vs Manchester United predictions for more stats and analysis
Nottingham Forest vs Arsenal - Sunday, October 18 (4.30pm)
Key stats
Dan Ndoye contributed three goals and three assists in his last four starts for Nottingham Forest and Switzerland
Forest failed to score in their first four home matches this season
Bukayo Saka has scored nine goals in his last 13 outings for Arsenal and England
The Gunners have won nine of their 10 matches in all competitions
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Team news
Nottingham Forest remain without striker Igor Jesus and defenders Nikola Milenkovic and Nicolo Savona.
Arsenal's Christos Tzolis, Piero Hincapie and William Saliba will miss the trip to the City Ground.
Need to know
Nottingham Forest have not scored in their first four home matches under Oliver Glasner, who endured a 3-1 defeat at his former club Crystal Palace last weekend.
Forest's forwards missed some good chances at Selhurst Park but they may struggle to create opportunities against champions Arsenal, who are chasing a 10th win in 11 matches in all competitions.
Score prediction: Nottingham Forest 0-1 Arsenal (27/5 with LiveScore Bet)
Read our full Nottingham Forest vs Arsenal predictions for more stats and analysis
Tottenham vs Coventry - Monday, October 19 (8pm)
Key stats
Tottenham have won three of their 22 home matches since the start of 2025-26
Mateus Fernandes has committed nine fouls in 252 minutes of league action for Spurs
Coventry centre-back Bobby Thomas averages 1.7 shots per 90 minutes this season
The Sky Blues have picked up only six cards in six league games
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Team news
Tottenham's Pedro Porro and Dejan Kulusevski will be assessed but Rodrigo Bentancur is suspended and Wilson Odobert, Mykhailo Mudryk and Xavi Simons are injured.
Coventry striker Taiwo Awoniyi is back from a ban but last season's top scorer Haji Wright remains sidelined.
Need to know
After a tough start to the season, Coventry have beaten Nottingham Forest 1-0 and Newcastle 4-1 in their last two matches.
They played some excellent football in Monday's win over the Magpies and are worth chancing at a big price against Tottenham, who have a dismal home record since the start of 2025-26.
Score prediction: Tottenham 1-2 Coventry (14/1 with LiveScore Bet)
Read our full Tottenham vs Coventry predictions for more stats and analysis
