Leaders Arsenal host fourth-placed Liverpool on Thursday
Following Ruben Amorim's exit, Manchester United go to Burnley on Wednesday
Also on Wednesday, Fulham entertain Chelsea in a London derby
The Premier League continues with a full round of fixtures between Tuesday and Thursday this week, with the highlight coming on Thursday when leaders Arsenal welcome champions Liverpool to the Emirates.
We have picked out a score prediction for all 10 games.
West Ham vs Nottingham Forest (Tuesday, 8pm)
The midweek action kicks off on Tuesday when two struggling sides meet at the London Stadium as West Ham take on Nottingham Forest.
Nuno Espirito Santo's position as Hammers boss is under threat following a dismal 3-0 loss at bottom-of-the-table Wolves on Saturday and another defeat against 17th-placed Forest, who are just four points and a place above them, could see him being sacked.
Forest have lost their last four games so are also in desperate need of three points, and they can edge it.
Score prediction: West Ham 0-1 Nottingham Forest
Bournemouth vs Tottenham (Wednesday, 7.30pm)
Bournemouth battled well against leaders Arsenal on Saturday, only losing 3-2 at home, but it is now 11 games without a win for the Cherries.
Spurs are unbeaten in three following a 1-1 draw with Sunderland and they can make it four with a narrow away win on the south coast.
Score prediction: Bournemouth 1-2 Tottenham
Brentford vs Sunderland (Wednesday, 7.30pm)
Brentford have won three of their last four games after Igor Thiago inspired them to a 4-2 success at Everton. The Brazilian striker netted a hat-trick to take his goal tally for the season up to 14.
Sunderland have slipped slightly in recent weeks after four consecutive draws but the Black Cats are still eighth, four points off the top four.
Only the top three have a better home record than the Bees this season, though, so Sunderland look set to struggle at the Gtech Community Stadium.
Score prediction: Brentford 2-0 Sunderland
Crystal Palace vs Aston Villa (Wednesday, 7.30pm)
Aston Villa bounced back from their defeat at Arsenal with a comfortable 3-1 home victory over Forest and they look set to stay in contention at the top with another win over Crystal Palace, who have failed to win any of their last five league games.
Score prediction: Crystal Palace 0-1 Aston Villa
Everton vs Wolves (Wednesday, 7.30pm)
Wolves finally got their first win of the season when they tore West Ham apart in the first half on Saturday and they will fancy their chances of getting something from their trip to Everton, who have won only one of their last five games.
Score prediction: Everton 1-1 Wolves
Fulham vs Chelsea (Wednesday, 7.30pm)
Fulham extended their unbeaten league run to five matches when they drew 2-2 with Liverpool on Sunday and they will make it difficult for Chelsea, who are set to have Calum McFarlane in interim charge again following Enzo Maresca's recent exit.
Score prediction: Fulham 1-1 Chelsea
Manchester City vs Brighton (Wednesday, 7.30pm)
City lost ground on Arsenal in the title race when they were held to a 1-1 draw at home by Chelsea on Sunday but they should get back on track with victory over Brighton, who have only won twice away from home in the top flight this season.
Score prediction: Manchester City 3-1 Brighton
Burnley vs Manchester United (Wednesday, 8.15pm)
Manchester United start life after Ruben Amorim with a trip to second-bottom Burnley. Darren Fletcher is set to be in charge of the Red Devils and he should be able to secure a morale-boosting victory against opponents who have only picked up three league wins all season.
Score prediction: Burnley 0-2 Manchester United
Newcastle vs Leeds (Wednesday, 8.15pm)
Newcastle are in better shape after consecutive wins over Burnley and Palace and they should have too much for Leeds, who have been poor on the road with just one away victory so far.
Score prediction: Newcastle 3-0 Leeds
Arsenal vs Liverpool (Thursday, 8pm)
Leaders Arsenal have won nine of their 10 home games this season and will want another statement victory on Thursday over Liverpool to solidify their position at the top.
Arne Slot's side are unbeaten in nine games in all competitions following a 2-2 draw at Fulham on Sunday but they have failed to convince in several of those outings and look set to fall to a damaging defeat at the Emirates.
Score prediction: Arsenal 2-1 Liverpool
