Benfica have just two wins from their 14 away matches against Spanish clubs
Real Madrid have triumphed in 22 of the last 23 European ties in which they were victorious in the first leg
Recommended bet: Real Madrid to win to nil
The last two meetings between Real Madrid and Benfica have been fiery encounters and the second leg of their Champions League play-off could be another simmering contest.
Benfica ended the league phase with a 4-2 victory over Real to clinch a play-off place at the expense of Marseille on goal difference.
The last-gasp win was achieved with a stoppage-time fourth goal from Benfica keeper Anatoliy Trubin, sparking scenes of wild celebration which Los Galacticos did not look on too fondly.
Los Blancos responded last week and secured a 1-0 win on the road and it all adds up to another intriguing clash between the giants of European football.
The latest Real Madrid vs Benfica odds are available on LiveScore Bet
Team news
Rodrygo is unavailable due to suspension, while Jude Bellingham (hamstring), Eder Militao (hamstring) and Dani Ceballos (calf) are also out.
Dean Huijsen is a major doubt for Real with a muscular problem.
Gianluca Prestianni is suspended, while Joao Veloso is out due to a shoulder problem; Benfica are otherwise in excellent shape for this fixture with no other notable absentees.
The stats
Real have won five of their last six matches against Portuguese opposition. Benfica have just two wins from their 14 away matches against Spanish clubs.
The Eagles have won eight of their last 11 two-legged European ties.
Real Madrid have triumphed in 22 of the last 23 European ties in which they were victorious in the first leg.
The latest Real Madrid vs Benfica odds are available on LiveScore Bet
Prediction
Real Madrid have a canny knack of winning Champions League matches when they really need to and it is hard to see them slipping up on Wednesday despite not being at their best recently.
Los Blancos were beaten by Osasuna last Sunday to relinquish the lead to Barcelona in the La Liga title race, but they have a good record against Portuguese opponents in this competition winning five of their last six meetings against Iberian opponents.
And to add weight to a Madrid victory, 22 of the last 23 knockout ties in which the Bernabeu boys have been involved have fallen their way and they are likely to be fired up for victory following last week's controversial incident involving Vinicius Junior.
Benfica have been shut out in three of their Last five road trips and Real Madrid are fancied to hold them at bay on Wednesday.
Back Real Madrid to win to nil at 2/1 with LiveScoreBet
The latest Real Madrid vs Benfica odds are available on LiveScore Bet
