Both teams have scored in seven of Newcastle's last nine at home
There have been at least three goals in PSV's last seven games
Recommended bet: Over 3.5 goals
With a trip to European champions Paris Saint-Germain set to close out their Champions League campaign, Newcastle will see this clash with PSV as a must-win as they target a top-eight finish in the league phase.
The Magpies currently sit 12th in the 36-team standings, two points outside of securing a spot in the last 16 and they have already beaten Benfica and Athletic Bilbao at St James' Park.
Eddie Howe's side are eighth in the Premier League table, but they were laboured in Sunday's goalless draw at bottom club Wolves and the injuries have totted up.
That will offer Dutch visitors PSV some hope and they are running away with the Eredivisie, sitting 16 points clear of Feyenoord at the summit.
A 4-1 win away to Liverpool at Anfield shows what Peter Bosz's side are all about and, with Newcastle having to manage a patched-up defence, it should be an entertaining night under the lights on Tyneside.
The latest Newcastle vs PSV odds are available on LiveScore Bet
Team news
Newcastle are expected to be without several players. including defenders Dan Burn, Emil Krafth, Valentino Livramento, Fabian Schar and Jamaal Lascelles.
William Osula and Jamaal Lascelles are also sidelined for the Magpies, but Anthony Elanga and Yoane Wissa will be hoping to start as Howe looks to freshen things up.
PSV are also in the midst of a mini-injury crisis with Ruben van Bommel, Alassane Plea, Myron Boadu, Nick Olij, Ricardo Pepi and Sergino Dest all expected to miss the trip to Tyneside.
The stats
Newcastle have lost only one of their last 14 home matches, which came against Man City in the first leg of their EFL Cup semi-final.
The Magpies have scored at least twice in 13 of their last 14 home fixtures, with three of their last five going over 3.5 goals.
Both teams have scored in all six of PSV's Champions League games, while nine of PSV's last 10 games have gone over 2.5 goals and they have kept only one clean sheet in seven.
The Dutch side have won 11 of their last 12 matches and they are chasing a seventh straight success.
Both teams have scored in seven of Newcastle's last nine home matches.
The latest Newcastle vs PSV odds are available on LiveScore Bet
Prediction
Defensive injuries are hampering Newcastle right now and a weakened rearguard does not bode well for the visit of PSV, who are streaking clear in the Eredivisie.
PSV have seen both teams score in all six of their Champions League matches this season and they highlighted their scoring power in a 6-2 win at home to Napoli and a 4-1 rout of Liverpool at Anfield.
The Magpies are dominant on home soil but they cannotafford to take the challenge of PSV lightly, especially given that they have won 11 of their last 12.
That said, the hosts can be explosive in their own right and that should ensure a high-scoring Champions League clash.
Howe's men have scored two or more goals in 13 of their last 14 at home, but they have managed only one clean sheet in their last nine at St James' Park.
