Lyon are unbeaten in six previous meetings with Fenerbahce, winning on four occasions Lyon have won four of their last five matches on home soil Recommended bet: Lyon to win @ 5/6
A 1-1 draw in Istanbul has this Champions League playoff tie hanging in the balance but Lyon should feel that they are in the stronger position ahead of the second leg fixture at the Groupama Stadium.
Lyon lost 2-1 away at Sparta Prague in the previous round but turned things around with a 3-0 home victory and they have made a winning start in Ligue 1, opening up with Saturday's 2-0 victory at Toulouse.
Paulo Fonseca's side showed their capabilities in Europe last season, winning seven of their eight matches to top the league phase of the Europa League.
Fenerbahce were also in last season's Europa League but they won only three of their eight matches in the league phase to finish 19th in the 36-team standings.
The Turkish side won home and away in the last qualifying round against Sturm Graz, and the presence of Talisca, Matteo Guendouzi, Vedat Muriqi and Nathan Ake shows that they have quality at their disposal.
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Team news
Lyon head coach Fonseca rotated his squad for the weekend win at Toulouse, but influential players such as Tyler Morton and captain Corentin Tolisso are expected to return for this crunch clash.
Centre-back Moussa Niakhate is set to miss out due to injury but Lyon are boosted by the return of Pavel Sulc and Nicolas Tagliafico, who has been freshened up after representing Argentina in the World Cup final.
Fenerbahce, meanwhile, are missing a number of players, with Mert Gunok, Caglar Soyuncu and Amara Diouf sidelined, while Marco Asensio and Kerem Akturkoglu are notable doubts.
Jayden Oosterwolde is closing in on a move to Roma and Cengiz Under and Mert Yandas have fallen out of favour.
The latest Lyon vs Fenerbahce odds are available on LiveScore Bet
The stats
Lyon are unbeaten in six previous meetings with Fenerbahce, winning on four occasions.
Lyon have won four of their last five matches on home soil, scoring at least twice in each victory.
Fenerbahce have won only three of their last eight away games, having suffered a 2-1 defeat at Genclerbirligi in their last road outing.
Fenerbahce have scored in each of their seven outings this season, with both teams scoring in their last three fixtures.
Five of Lyon's last six home matches have featured at least three goals.
Both teams have scored in four of the last five meetings between the sides.
The latest Lyon vs Fenerbahce odds are available on LiveScore Bet
Prediction
The first-leg encounter was evenly matched, with the 1-1 draw seeing both teams have 12 shots and each hitting the target five times.
However, the pendulum should swing in Lyon's favour on French soil and they were emphatic 3-0 winners at home to Sparta Prague in the last qualifying round.
Fenerbahce have a lot of familiar names in the squad, but there is a lopsided look to the team and they have already drawn 1-1 away at Polish side Gornik Zabrze and lost 2-1 on the road at Genclerbirligi this season.
Lyon were able to ring the changes for Saturday's 2-0 win at Toulouse, meaning key men such as Sulc, Tolisso and Morton should be fit and raring to go.
Score prediction: Lyon 2-1 Fenerbahce
Back Lyon to win @ 5/6 with LiveScore Bet
The latest Lyon vs Fenerbahce odds are available on LiveScore Bet
