Struggling Manchester United travel to Como
Aston Villa bid to stay perfect at home to Viking
Arsenal face a tough trip to Bayern Munich
There are nine Champions League games on Wednesday, including an anticipated clash between Bayern Munich and last season's beaten finalists Arsenal at the Allianz Arena.
Como vs Manchester United – Wednesday October 21 (5.45pm)
Key stats
Como are unbeaten at home this season (W3 D1)
Manchester United are without a win in six matches
Recommended bet
Team news
Como are missing Assane Diao due to a thigh injury while Trevoh Chalobah and Moise Kean will both need to be assessed.
Leny Yoro is suspended for Manchester United and Manuel Ugarte, Patrick Dorgu and Benjamin Sesko are ruled out through injury. Ayden Heaven, Kobbie Mainoo, Lisandro Martinez and Luke Shaw are doubts.
Need to know
United’s winless run stretched to six games with Sunday’s 1-1 draw at Leeds and there is huge pressure on head coach Michael Carrick, who witnessed his side lose 2-0 at Atletico Madrid on matchday two.
Como are a strong outfit and they continue to impress under manager Cesc Fabregas, who has his team fifth in Serie A and will sense an opportunity to land a second Champions League win.
Score prediction: Como 3-1 Manchester United (13/1 with LiveScore Bet)
Lille vs Galatasaray – Wednesday October 21 (5.45pm)
Key stats
Lille are unbeaten at home in Ligue 1 this season
Galatasaray have lost eight of their last away matches in the Champions League
Recommended bet
Team news
Ethan Mbappe is suspended for Lille, who are missing Tiago Santos because of a knee injury and have doubts over Ayase Ueda and Berke Ozer.
Rafael Leao is set to miss for Galatasaray with a groin problem while there are doubts over the availability of Wilfried Singo.
Need to know
Galatasaray have endured some difficult times on their travels in the Champions League, losing 10 of their last 12 away games in the competition and failing to score in half of those.
Another disappointing road result is expected when they head to Lille, who are unbeaten in their last three home games and can claim their first win of the league phase.
Score prediction: Lille 2-0 Galatasaray (19/2 with LiveScore Bet)
Aston Villa vs Viking – Wednesday October 21 (8pm)
Key stats
Aston Villa thrashed Fenerbahce 6-0 on matchday two
Viking have scored in their last 10 away games
Recommended bet
Team news
Taylor Harwood-Bellis is ineligible for Aston Villa, who are also set to be without the injured quintet of Aaron Wan-Bissaka, Ian Maatsen, Amadou Onana, Matteo Ruggeri and Modou Cisse.
Viking are without the services of Martin Ove Roseth, Nick D'Agostino, Veton Berisha and Anders Bærtelsen.
Need to know
After a slow start to the season, Villa have improved in recent weeks and are on a five-game unbeaten run heading into this contest, with four wins and a draw.
Unai Emery’s side should pick up the win on home soil, as they did in matchday two, but Viking showed their quality in a 3-3 draw against Bayern Munich last week and the visitors can play their part in an entertaining contest.
Score prediction: Aston Villa 3-1 Viking (8/1 with LiveScore Bet)
Bayern Munich vs Arsenal – Wednesday October 21 (8pm)
Key stats
Bayern Munich have won all four home games this season, scoring 23 goals
Arsenal have won five of their six away matches this term
Recommended bet
Team news
Bayern Munich forward Michael Olise is suspended while Jamal Musiala is sidelined with a thigh issue and Kim Min-jae will need to be assessed.
Arsenal are missing the injured trio of Piero Hincapie, Christos Tzolis and William Saliba.
Need to know
Bayern have scored 36 goals across their 10 matches this season and it is notable that 23 of those have come at the Allianz Arena, which suggests there will be plenty of strikes on Wednesday.
Arsenal are not as strong defensively without Saliba sidelined and this was evident in a 3-0 loss at Brighton before the international break. The Gunners still have their own attacking threats and they put three past Lille on matchday two.
Score prediction: Bayern Munich 4-2 Arsenal (24/1 with LiveScore Bet)
Club Brugge vs Lens – Wednesday October 21 (8pm)
Key stats
Club Brugge’s first two league-phase matches have seen a total of 12 goals
Lens have scored two or more in four of their last five away games
Recommended bet
Team news
Club Brugge's injury list is relatively small with Joel Ordonez and Bjorn Meijer the only absentees.
Lens are missing Maik Nawrocki and Abdallah Sima while this game comes too soon for Jonathan Gradit, who returned to individual training last week.
Need to know
Club Brugge are on a five-game winning run since a matchday one loss to Aston Villa and they have been in superb scoring form, netting 15 times during this perfect period.
A 4-3 win over Inter Milan last week is evidence of Brugge’s quality and they will feel optimistic of accounting for Lens, who have been inconsistent on their travels with two wins, two losses and a draw.
Score prediction: Club Brugge 3-2 Lens (12/1 with LiveScore Bet)
Inter Milan vs Shakhtar Donetsk – Wednesday October 21 (8pm)
Key stats
Inter Milan have lost just one of their last 12 home games
Shakhtar Donetsk have failed to win their last three away matches in Europe in normal time
Recommended bet
Team news
Inter captain Lautaro Martinez is sidelined until the next international break in November while John Stones is still struggling with a flexor problem and Benjamin Pavard and Curtis Jones are sidelined.
Eguinaldo and Alaa Ghram are both out for Shakhtar, who also have doubts over Marlon Santos and Diego Arroyo.
Need to know
Inter have had no problems scoring goals at home, netting 18 times in five matches, and they should be able to notch a few more when hosting Shakhtar.
But the Nerazzurri have kept just one clean sheet in those five fixtures and they conceded four in the 4-3 loss to Club Brugge on matchday two, so there is hope Shakhtar can at least get on the scoresheet.
Score prediction: Inter Milan 3-1 Shakhtar Donetsk (8/1 with LiveScore Bet)
Real Betis vs Feyenoord – Wednesday October 21 (8pm)
Key stats
Real Betis have won their first two league-phase matches by 3-2 scorelines
Feyenoord lost 2-1 at Betis in the league phase of last season’s Europa League
Recommended bet
Team news
Betis are missing Junior Firpo and Cucho Hernandez due to injury while Aitor Ruibal is a doubt.
Feyenoord are without Goncalo Borges, Jordan Bos, Jakub Moder, Reiss Nelson, Bart Nieuwkoop, Gijs Smal and Shaqueel Van Persie.
Need to know
There has been plenty of entertainment in Real Betis’s last three matches, with 5-2 and 3-2 wins over Osasuna and Porto followed by a 5-2 loss to Barcelona.
Feyenoord have also felt Barcelona’s wrath, losing 5-1 when visiting the Catalans on matchday one, but the Dutch outfit have racked up 7-1 and 4-3 wins in their last two away fixtures.
Score prediction: Real Betis 3-2 Feyenoord (12/1 with LiveScore Bet)
Real Madrid vs RB Leipzig – Wednesday October 21 (8pm)
Key stats
Real Madrid have won all six home matches this season
RB Leipzig have lost their last four away games
Recommended bet
Team news
Rodrygo, Ferland Mendy and Raul Asencio are injured for Madrid although Vinicius Junior is available as his suspension only relates to domestic football.
Leipzig are without Christoph Baumgartner and Assan Ouedraogo due to injury.
Need to know
Real Madrid have responded well from the derby defeat to Atletico, winning three matches in a row and scoring nine goals in the process.
Los Blancos are a perfect six from six at home this season and they can dispatch an RB Leipzig side who have lost their last four away fixtures, conceding 15 goals during that period.
Score prediction: Real Madrid 4-1 RB Leipzig (19/2 with LiveScore Bet)
Sporting vs LASK – Wednesday October 21 (8pm)
Key stats
Sporting have won their first two league-phase matches
LASK have lost to AEK Athens and Liverpool in their two games
Recommended bet
Team news
Nuno Santos and Rodrigo Zalazar are both unavailable because of injury and there are doubts over the fitness of Zeno Debast.
George Bello and Moses Usor will need to be assessed after missing the last two games for LASK.
Need to know
LASK have failed to score in their two away matches in the Champions League, drawing blanks at Celtic and AEK Athens, and those attacking issues could be exposed by a solid Sporting side.
Sporting are unbeaten in 10 games this season and they recorded a 2-0 win at Lens on matchday two, evidence of their defensive resolve.
Score prediction: Sporting 2-0 LASK (13/2 with LiveScore Bet)
