Liverpool, Arsenal and Manchester City all face testing away fixtures
Real Madrid will also be on the road at AEK Athens
Real Betis will put their perfect record on the line at Borussia Dortmund
Matchday four of the Champions League continues on Wednesday with nine more games, including Liverpool's trip to Fenerbahce and Arsenal's away clash with Slavia Prague.
AEK Athens vs Real Madrid – Wednesday November 4 (5.45pm)
Key stats
AEK Athens have lost four of their last five matches in all competitions
Real Madrid have won 12 of their 14 games since the return of Jose Mourinho
Los Blancos have only kept two clean sheets in their last 10 matches
Recommended Bet
Team news
Illness is causing problems for AEK Athens with Joao Mario definitely out and Lazaros Rota rated doubtful. Goalkeeper Thomas Strakosha is also struggling with a hand issue but former Real forward Luka Jovic is set to lead the line.
Federico Valverde is back in training after a hamstring issue and could feature for Real, who will definitely be without Rodrygo (knee) and Raul Asencio (leg).
Need to know
AEK Athens have lost eight of their last nine games in the Champions League group stage/league phase, but their one win during that run did come on home soil against LASK this season.
Real have won 12 of 14 this season, including all three matches in the Champions League, but they are defensively vulnerable, with their only clean sheets in their last 10 coming against Villarreal and Racing Santander in La Liga.
Score prediction: AEK Athens 1-2 Real Madrid (8/1 with LiveScore Bet)
Fenerbahce vs Liverpool – Wednesday November 4 (5.45pm)
Key stats
Fenerbahce have lost back-to-back games and have only won once in five
Liverpool are three wins from three in this season's Champions League
The Reds have never beaten a Turkish team on their travels in the European Cup/Champions League
Recommended Bet
Team news
Nathan Ake (hamstring) and Marco Asensio (knee) are definitely out for Fenerbahce while there are also doubts surrounding Kojo Peprah Oppong, who was forced off in the weekend defeat to Goztepe.
Liverpool have no fresh injury concerns but Conor Bradley (knee), Hugo Ekitike (Achilles), Jeremie Frimpong (hamstring) and Giovanni Leoni (knee) all remain on the sidelines.
Need to know
Dirk Kuyt is in interim charge of Fenerbahce following the departure of Ismail Kartal. The Dutchman will be a familiar face to Liverpool supporters having made nearly 300 appearances for the club and scored for them in the 2007 Champions League final.
The Reds famously lifted the Champions League in Istanbul in 2005, but they have only won four of their 11 previous meetings with Turkish teams in Europe's premier club competition and all of those victories came on home soil.
Score prediction: Fenerbahce 1-4 Liverpool (13/1 with LiveScore Bet)
Read our full Fenerbahce vs Liverpool predictions for more stats and analysis
Borussia Dortmund vs Real Betis – Wednesday November 4 (8pm)
Key stats
Borussia Dortmund have registered nine wins and just one defeat from their last 13 games
Real Betis are three wins from three in what is their first Champions League campaign since 2005-06
The Spanish side have only lost one of their last 11 matches
Recommended Bet
Team news
Dortmund head coach Niko Kovac has a near fully-fit squad to choose from with defender Kaua Prates the only confirmed absentee with a muscular issue.
Real Betis are also nearing a clean bill of health but this match will come too soon for Cucho Hernandez (calf) and Junior Firpo (muscular).
Need to know
Dortmund's only defeat in their last 13 games did come in the Champions League against Bodo/Glimt on matchday two, while three of their last seven matches have ended all square.
Real Betis are playing in the Champions League for the first time in over 20 years but they are a perfect three wins from three so far, beating Feyenoord and Porto on home soil off the back of winning away at Lille.
Score prediction: Borussia Dortmund 2-2 Real Betis (19/2 with LiveScore Bet)
Lens vs Como – Wednesday November 4 (8pm)
Key stats
Lens have lost their last two Champions League games without scoring
Como are on a five-match winning run across all competitions
Cesc Fabregas' side thrashed Manchester United 4-1 in their last European fixture
Recommended Bet
Team news
Lens have problems in the final third with Abdalllah Sima (thigh) and Odsonne Edouard (adductor) both ruled out. Defender Ismaelo Ganiou is also missing due to a knee issue.
Trevoh Chalobah is a major doubt for Como with a muscular problem and he could remain on the treatment table alongside Assane Diao (hamstring) and Moise Kean (shin).
Need to know
Lens have lost six of their last 11 games and have suffered back-to-back defeats in the Champions League to Sporting CP and Club Brugge without scoring.
Como duo Nico Paz and Anastasios Douvikas have a combined eight goal involvements in this season's Champions League
Score prediction: Lens 0-2 Como (21/2 with LiveScore Bet)
PSV Eindhoven vs Club Brugge – Wednesday November 4 (8pm)
Key stats
PSV were 7-0 winners over Willem II in the Eredivisie on Saturday
Club Brugge have won eight matches on the spin across all competitions
The Belgians beat Inter Milan 4-3 on their last Champions League away day
Recommended Bet
Team news
Winger Sami Ouaissa has been ruled out for PSV due to a hamstring issue and Paul Wanner (foot) and Sam Lammers (muscular) face late fitness checks.
Ecuadorian defender Joel Ordonez is yet to play for Club Brugge this season but otherwise head coach Ivan Leko has a fully fit squad to choose from.
Need to know
PSV have averaged more than three goals-per-game across their last seven home fixtures and they had seven different scorers in Saturday's 7-0 thrashing of Willem II.
Club Brugge have scored a minimum of three goals in seven of their last eight matches and the back of the net has been hit 15 times across their three Champions League fixtures.
Score prediction: PSV Eindhoven 2-3 Club Brugge (14/1 with LiveScore Bet)
Porto vs Napoli – Wednesday November 4 (8pm)
Key stats
Porto are a perfect 12 wins from 12 domestically but have lost all three matches in the Champions League
Napoli are winless in their last six Champions League away games, losing five of those
The Partenopei have lost four of their last six away matches in all competitions
Recommended Bet
Team news
Porto are sweating over the fitness of Oskar Pietuszewski (thigh) and William Gomes (ankle), who are both rated as doubts.
Napoli's injury concerns are extensive with Benoit Badiashile (muscular), Giovanni Di Lorenzo (adductor), Stanislav Lobotka (ankle), David Neres (thigh), Mathias Olivera (muscular), Alisson Santos (thigh) and Leonardo Spinazzola (leg) all out and Kevin De Bruyne (ankle), Rasmus Hojlund (illness) and Vanja Milinkovic-Savic (muscular) facing late fitness checks.
Need to know
Porto's domestic and European form could not be more contrasting but they will be facing a Napoli side that are poor on their travels and could be missing as many as 10 first-team players through injury.
Napoli have failed to score in two of their last three away matches and have lost on their travels at Villarreal in the Champions League and Serie A's bottom club Venezia over recent weeks.
Score prediction: Porto 1-0 Napoli (15/2 with LiveScore Bet)
RB Leipzig vs Manchester City – Wednesday November 4 (8pm)
Key stats
RB Leipzig have lost nine of their last 11 Champions League games
Manchester City have won four of their previous six meetings with Leipzig
City's Erling Haaland has scored 61 goals in just 60 Champions League appearances
Recommended Bet
Team news
Assan Ouedraogo remains sidelined for Leipzig with a shoulder issue while Maxime Esteve is doubtful with the knock that ruled him out of Saturday's Bundesliga win at Schalke.
City's only confirmed absentee is Antoine Semenyo, who is not expected to return from his knee injury until the middle of next month.
Need to know
This will be the seventh time these two teams have met in the Champions League since 2021, with City registering four wins to Leipzig's one.
Both teams have scored in five of those six previous head-to-heads, the exception being the clean sheet City kept in a 7-0 thrashing of Leipzig at the Etihad Stadium in March 2023.
Score prediction: RB Leipzig 1-3 Manchester City (17/2 with LiveScore Bet)
Slavia Prague vs Arsenal – Wednesday November 4 (8pm)
Key stats
Slavia Prague are winless in their last 18 European games (D6,L12)
Arsenal are unbeaten in their last 18 matches in the Champions League (excluding penalty shootouts)
The Gunners won 3-0 away to Slavia in last season's league phase
Recommended Bet
Team news
Star striker Lukas Provod is dealing with a muscular issue for Slavia and is a doubt alongside Ivan Schranz, Ange N'Guessan (both unspecified), Samuel Isife (illness) and Jakub Markovic (muscular), while Adonija Ouanda (muscular) and Elias Pitak (ankle) will definitely sit this one out.
Bukayo Saka (quad) and William Saliba (back) remain unavailable for Arsenal while Eberechi Eze is dealing with an unspecified fitness problem and may not be risked.
Need to know
Slavia Prague may not have won any of their last 18 European games but it is actually no win in 22 matches for the Czech side when only factoring in the Champions League (outside of qualifiers), with their last win in the competition proper coming against FCSB in September 2007.
Arsenal's 18-match unbeaten run in the Champions League has been accompanied by 11 clean sheets, with their two European wins this season both coming to nil.
Score prediction: Slavia Prague 0-3 Arsenal (13/2 with LiveScore Bet)
Read our full Slavia Prague vs Arsenal predictions for more stats and analysis
Viking vs Sabah – Wednesday November 4 (8pm)
Key stats
Viking are a perfect 12 wins from 12 on home soil in this season's Eliteserien
The Norwegian champions drew 3-3 with Bayern Munich in their last European home fixture
Sabah lost away to Aarhus and Hapoel Be'er Sheva in Champions League qualifying
Recommended Bet
Team news
Anders Baertelsen (foot), Veton Berisha (thigh), Sondre Bjorshol (knee), Nick D'Agostino (knee) and Martin Ove Roseth (muscular) are all sidelined for Viking.
Sabah's only fitness concern surrounds Serbian midfielder Veljko Simic, who is a doubt with an unspecified problem.
Need to know
Viking have won all 12 of their home matches in this season's Eliteserien and they have beaten Dinamo Zagreb in Champions League qualifying and drawn with Bayern Munich in the league phase at Viking Stadion.
Sabah have lost away to Aarhus, Hapoel Be'er Sheva and been comprehensively beaten 4-0 by a struggling Manchester United in Europe this season and they head to Norway winless in their last three games.
Score prediction: Viking 3-1 Sabah (17/2 with LiveScore Bet)
