Atletico Madrid host Bayern Munich in one of the standout ties on Tuesday night
Barcelona and Aston Villa meet in a battle between two of the competition's most entertaining teams
Holders Paris Saint-Germain travel to Villarreal looking to maintain their perfect start
The Champions League returns with another action-packed midweek of matches featuring several heavyweight clashes across Europe.
Galatasaray vs VfB Stuttgart – Tuesday November 3 (5.45pm)
Key stats
Six of Galatasaray's last seven European matches have produced over 2.5 goals
Stuttgart have scored in each of their last 11 Champions League away matches
Victor Osimhen has scored 10 goals in 10 competitive appearances this season
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Team news
Galatasaray boss Okan Buruk faces a selection dilemma over whether to start Rafael Leao or Barıs Alper Yilmaz on the left of a 4-2-3-1 system with in-form Osimhen as the spearhead.
Stuttgart will travel to Turkey without midfielder Angelo Stiller, left winger Leo Sauer, and right back Josha Vagnoman as the trio recover from injuries.
Need to know
Osimhen has been pivotal to Galatasaray's success as the Turkish giants have bounced back strongly from their Barcelona defeat with four consecutive wins across all competitions, scoring 11 goals and conceding only three.
Alongside Arsenal and PSV Eindhoven, Stuttgart have conceded the fewest goals in the League Stage, with just one going into their net from wins against Slovan Bratislava and Viking Stavanger, plus a draw at home to 10-man Atletico Madrid.
Score prediction: Galatasaray 2-1 Stuttgart (15/2 with LiveScore Bet)
Shakhtar Donetsk vs Sporting Lisbon – Tuesday November 3 (5.45pm)
Key stats
Shakhtar have lost only once in their last 13 matches — 1-0 against Inter Milan at the San Siro
Sporting have failed to win eight of their last 10 Champions League away matches
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Team news
Shakhtar boss Arda Turan rested defenders Vinicius Tobias, Pedro Henrique and Mykola Matviyenko, as well as striker Kaua Elias and in-form winger Alisson, against Obolon. All of them are set for recalls in a much-changed side.
Sporting are still without defender Zeno Debast, but midfielder Rodrigo Zalazar returns from a five-game lay-off, and Geny Catamo is likely to earn a recall to the starting XI after scoring as a substitute against Casa Pia.
Need to know
Shakhtar won their last Champions League 'home' match 3-1 against AEK Athens at Stamford Bridge last month.
Sporting removed Rui Borges from his position as head coach on Sunday, so reserve team boss Tiago Fernandes will take interim charge for now.
Score prediction: Shakhtar Donetsk 1-1 Sporting Lisbon (23/4 with LiveScore Bet)
Atletico Madrid vs Bayern Munich – Tuesday November 3 (8pm)
Key stats
Atletico have scored two or more goals in five of their six home games this season
All three of Bayern's League stage matches this season have featured at least four goals
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Team news
Morten Hjulmand is suspended for the hosts after his red card against Stuttgart, while Johnny Cardoso and Koke remain injury doubts.
Injuries forced Ismael Saibari, Serge Gnabry and Michael Olise off in last weekend's 2-2 Bundesliga draw with Borussia Dortmund, but the French winger stands a chance of playing on Tuesday. Manuel Neuer may also be available to don the gloves again, but Luis Diaz, Jamal Musiala and Bara Sapoko Ndiaye remain sidelined.
Need to know
Atletico are traditionally extremely difficult to beat at home and have won ten of their previous 12 Champions League league-stage matches in Madrid.
Bayern Munich will again be led by assistant Aaron Danks as Vincent Kompany recovers from meningeal irritation.
Score prediction: Atlético Madrid 2-2 Bayern Munich (17/2 with LiveScore Bet)
Barcelona vs Aston Villa – Tuesday November 3 (8pm)
Key stats
Barcelona are unbeaten in their last 15 home matches against English opposition (W10 D5)
All three of Barcelona's Champions League matches this season have seen both teams score and over 2.5 goals registered.
Aston Villa have won all three league-phase matches while scoring 12 goals
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Team news
With Andreas Christensen, Eric Garcia, Jules Kounde and Xavi Espart out, Hansi Flick was forced to hand Brian Farinas a debut at right-back and deploy Frenkie de Jong in central defence at the weekend.
Emiliano Buendia and Joao Gomes are set for Aston Villa recalls as there are no new injury concerns for Unai Emery to contend with, although Amadou Onana, Matteo Ruggeri and Aaron Wan-Bissaka remain absent.
Need to know
Barcelona and Aston Villa have been among the most entertaining sides in this season's competition, with the Blaugrana having scored 11 goals in three matches but also struggling for defensive solidity.
Villa have been sensational going forward and arrive in Spain full of belief. However, Barcelona's outstanding record against English clubs at Nou Camp is daunting.
Score prediction: Barcelona 3-2 Aston Villa (13/1 with LiveScore Bet)
Bodo/Glimt vs Lille – Tuesday November 3 (8pm)
Key stats
Bodo/Glimt have won their last six home Champions League matches
With four goals scored, ten goals conceded and zero points, Lille sit second bottom of the League stage standings
Lille have conceded seven second-half goals in Europe this season
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Team news
Haitam Aleesami could earn a recall, but Kjetil Knutsen is expected to keep faith with the Glimt line-up that earned a crucial 3-2 league win over Viking Stavanger last Friday.
Lille could be unchanged from their 1-0 victory over Lens on Friday, a result which halted a four-game winless streak.
Need to know
Bodo/Glimt's perfect home form in Europe this year has made them a team to be feared — as have the often unwelcoming conditions at Aspmyra Stadion.
Lille have struggled after half-time in continental competition and could find themselves under sustained pressure as the game progresses.
Score prediction: Bodo/Glimt 2-1 Lille (21/2 with LiveScore Bet)
Feyenoord vs Inter Milan – Tuesday November 3 (8pm)
Key stats
Feyenoord have lost 10 of their last 13 major European matches
Inter are unbeaten in their last 13 Champions League matches against Dutch opposition
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Team news
Defender Jeremiah St. Juste misses the clash after sustaining a shin injury and Jakub Moder is undergoing tests to determine the extent of his injury. But Feyenoord welcome back striker Shaqueel van Persie and winger Reiss Nelson.
Carlos Augusto is pencilled in to replace suspended Inter defender Alessandro Bastoni with either Pio Esposito or Ange Bonny to partner Marcus Thuram up front in the absence of Inter skipper Lautaro Martinez — provided they recover from illness.
Need to know
Feyenoord have made the fewest changes to their starting XI in this season's Champions League, with just one so far.
Inter are under pressure to get a win in Rotterdam after being beaten in seven of their last nine Champions League games and narrowly escaping with a 1-0 win at home to Shakhtar Donetsk on matchday three after being reduced to 10 men.
Score prediction: Feyenoord 1-2 Inter Milan (7/1 with LiveScore Bet)
LASK vs Slovan Bratislava – Tuesday November 3 (8pm)
Key stats
LASK have won four of their last six home European matches
Slovan have lost all 11 of their Champions League proper matches
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Team news
LASK will be without American left wing-back George Bello, while midfield duo Cheikne Kebe and Art Smakaj, plus French striker Ramiz Harakate are unavailable.
Captain Andraz Sporar is likely to play after missing the last match, but fellow forward Roman Cerepkai is injured and strikers Manasse Kianga and Adam Griger are ineligible to feature.
Need to know
LASK's home form gives them a slight edge against visitors who have often struggled away from Slovakia.
Slovan have lost on all four of their previous away trips to face Austrian clubs.
Score prediction: LASK 2-1 Slovan Bratislava (7/1 with LiveScore Bet)
Manchester United vs Roma – Tuesday November 3 (8pm)
Key stats
Manchester United are without a win in their last nine matches in all competitions
The Red Devils have been reduced to 10 men in two of their last five matches
Roma's Champions League opponents have received eight yellow cards in three games
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Team news
Patrick Dorgu is available again for United, who are still without Benjamin Sesko, Marcus Rashford and Luke Shaw. Lisandro Martinez can play, despite being sent off at Chelsea on Saturday.
Donyell Malen is set to start up front, with Gian Piero Gasperini likely to opt for a reinforced midfield with Bryan Cristante, Marten De Roon, and Niccolo Pisilli.
Need to know
Despite their poor recent results, United possess a superb European home record and have won all four previous home meetings against Roma.
Roma are scoring freely under Gasperini but remain vulnerable defensively away from home in Europe.
Score prediction: Manchester United 2-1 Roma (15/2 with LiveScore Bet)
Villarreal vs Paris Saint-Germain – Tuesday November 3 (8pm)
Key stats
Twelve of Villarreal's last 14 home matches have seen both teams score and over 2.5 goals
PSG have won their last six matches by margins of at least two goals
Recommended Bet
Team news
Villarreal will have to cope without key Canadian midfielder Nathan Saliba and Moroccan winger Ilias Akhomach. Captain Gerard Moreno was injured in the last league match and looks set to miss out.
PSG are without Nuno Mendes, Khvicha Kvaratskhelia and Ousmane Dembele, but Luis Enrique is expected to name a strong lineup, possibly including Marquinhos.
Need to know
PSG arrive in exceptional form and look increasingly settled under their Spanish coach. Villarreal can trouble anyone at home but often leave space defensively.
The visitors appear slightly stronger across the pitch and should have enough quality to claim all three points.
Score prediction: Villarreal 1-3 Paris Saint-Germain (9/1 with LiveScore Bet)
