Fantasy football bosses across the world wince when one of their star players hits the deck — and a spell in the treatment room is never good news.
Keep this page bookmarked to stay up to date with all the Premier League injuries and expected return dates throughout the 2021-22 season.
Granit Xhaka (knee): Midfielder was taken off against Tottenham and has been ruled out until December.
Bukayo Saka (knock): England international was taken off at half-time against Crystal Palace and is battling to be fit for the Aston Villa game.
Bertrand Traore (Thigh): Missed the defeat to Wolves but is battling to be fit for Friday's game at Arsenal.
Leon Bailey (thigh): Speedster is expected to return at the Emirates after being taken off against Everton last month.
Trezeguet (knee): Suffered ligament damage against Liverpool in April and is expected to be out until the new year. The winger posted a photo of himself on an exercise bike in August as he steps up his recovery following an operation.
Yoane Wissa (ankle): The winger twisted his ankle prior to the Chelsea clash and will miss the weekend's action.
Vitaly Janelt (thigh): Missed the Chelsea clash and will face a late fitness test.
Josh Dasilva (hip): Midfielder was ruled out of the Championship play-offs in April with no date set for his return.
Mads Sorensen (knee): Dane is a long-term injury with medial ligament damage.
Shandon Baptiste (shoulder): No date set for his return from a dislocated shoulder.
Adam Webster (thigh): There is an outside chance that he will be available against Manchester City after returning to training.
Steven Alzate (ankle): Seagulls ace underwent surgery on an ankle injury and is out until 2022.
Danny Welbeck (thigh): Striker is struggling with a hamstring strain and will be referred to a specialist.
Ben Mee (knock): Sean Dyche will make a late decision ahead of a three-game week for the Clarets.
Matej Vydra (lower back): Looks unlikely to feature with a busy week ahead for Burnley.
Charlie Taylor (other): Will face a late decision ahead of multiple games next week.
Dale Stephens (ankle): Defender had surgery earlier this summer with and there is no date set for his return.
Kevin Long (calf): Irish centre-back needed surgery and is not yet ready to return.
Romelu Lukaku (ankle): Limped off with an ankle injury against Malmo and will take a while to recover, according to Thomas Tuchel.
Timo Werner (hamstring): Tweaked his hamstring on Wednesday night and is currently being assessed.
Christian Pulisic (ankle): American had a setback in his recovery and will miss the Norwich game.
Wilfried Zaha (other): An unexpected absentee from the Arsenal game but Roy Hodgson should have his star man back for the Newcastle clash.
Eberechi Eze (Achilles): Rising star looks set to make a quicker-than-expected recovery from his Achilles' injury but will not be available this weekend.
Nathan Ferguson (Achilles): Full-back went down shortly after team-mate Eze and is unlikely to feature before January.
Abdoulaye Doucoure (foot): Star midfielder has suffered a stress fracture in his foot and will miss a lengthy period of time
Richarlison (knee): Brazilian is in line to face former side Watford after missing several weeks.
Andre Gomes (calf): Struggling with a calf issue but could return this weekend if he passes a fitness test.
Dominic Calvert-Lewin (thigh): Striker's thigh injury will keep him out for several more weeks.
Fabian Delph (shoulder): No date has been set for the veteran midfielder's return.
Kalvin Phillips (calf): Influential midfielder is on the road to recovery but will not be in the squad against Wolves.
Robin Koch (pelvis): Defender is in the US for an operation to fix a 'problem in his pubis'.
Patrick Bamford (ankle): Hitman has been ruled out until early November.
Luke Ayling (knee): Right-back does not have a date set for his return and Marcelo Bielsa has revealed he will need a minor operation to clear the issue.
Junior Firpo (knock): The full-back will not be in Marcelo Bielsa's squad against Wolves.
Youri Tielemans (lower back): Was withdrawn against Spartak Moscow but will make the trip to Brentford.
Wilfred Ndidi (thigh): Midfielder is set to be out until early November at the minimum.
Jonny Evans (ankle): Faces a fitness test ahead of the visit of former club Manchester United.
Wesley Fofana (shin): Centre-back looks set to be out until 2022 after requiring surgery on a broken fibula he suffered after a horrific challenge in pre-season.
James Justin (knee): Full-back is out until late October at the earliest but has begun rehab work.
Ayoze Perez (illness): Did not travel to Russia for the Europa League but should be fine for the weekend after a couple of day's rest.
Timothy Castagne (hamstring): After returning from a thigh injury, a hamstring tweak has delayed his return.
Thiago Alcantara (calf): Midfielder is closing in on a return.
Harvey Elliott (ankle): Suffered a broken ankle and is a long-term absentee.
Curtis Jones (groin): Picked up an injury on international duty with England Under-21s duty and will face a late test for the Manchester United trip.
Ferran Torres (foot): Spain ace suffered a small fracture on his right foot while playing for his country.
Bruno Fernandes (knock): Is a doubt for the game against Liverpool and will face a late fitness test.
Raphael Varane (groin): Frenchman was injured in the Nations League final and is out until late October.
Anthony Martial (knock): Frenchman has returned to training and could be in the squad for the Liverpool game.
Fred (thigh): Pulled a muscle in midweek and may not be ready for the Liverpool clash.
Marcus Rashford (dead leg): Will face a late fitness test but is expected to be fit for Sunday's game.
Jonjo Shelvey (suspended): Misses the trip to Crystal Palace after his red card against Tottenham.
Martin Dubravka (foot): Magpies keeper needed surgery earlier this summer after picking up a stress fracture but has returned to training.
Paul Dummett (calf): Welsh defender suffered a setback in September and is set to miss more time.
Freddie Woodman (hip): Stopper missed the clash with Wolves but is nearing a return and could face Tottenham if he is declared fit.
Billy Gilmour (unavailable): The Chelsea loanee is unable to face his parent club.
Todd Cantwell (calf): Midfielder faces a late fitness test with an Achilles issue.
Sam Byram (thigh): Hamstring issues have kept the full-back out of action since 2020 with no date set for his return.
Christoph Zimmermann (ankle): Defender is struggling with an ankle injury.
Przemylsaw Placheta (lacking match fitness): Working on his fitness and could be in line for a spot in the squad at Stamford Bridge.
James Ward-Prowse (suspended): The Saints skipper will miss a rare start due to suspension.
Che Adams (unspecified): Ruled out last weekend but not expected to be on the sidelines long-term.
Jack Stephens (knee): Set to miss several months after damaging a tendon in his knee.
Matt Doherty (knock): Out of the West Ham match after picking up a knock on Ireland duty.
Ryan Sessegnon (knock): Left-back has no date set for his return.
Josh King (knee): Has returned to training and in line to return against former side Everton.
Nicolas N'Koulou (unspecified): Cameroon ace has been ruled out until early November.
Francisco Sierralta (thigh): Has returned to light training but this weekend will come too soon.
Christian Kabasele (thigh): Beginning rehab following a hamstring injury against Leeds.
Peter Etebo (thigh): Tore a quad muscle against Newcastle and faces four months out.
Kiko Femenia (hip): Faces a late fitness test after picking up a knock in the heavy defeat to Liverpool.
Vladimir Coufal (groin): Has missed the last two games after pulling out of international duty with a groin problem.
Alex Kral (Coronavirus): Tested positive for coronavirus ahead of the Everton game and remains unavailable.
Trincao (coronavirus): Is available for the game against Leeds.
Jonny (knee): Spaniard needed surgery on a season-ending ACL injury in April and is likely to be out until the new year.
Pedro Neto (knee): Winger had surgery on his knee in April and has begun his rehab ahead of a potential return in October.
Yerson Mosquera (muscular injury): Youngster went down with a non-contact injury just five minutes into his debut and is set for a spell on the sidelines.
Hugo Bueno (thigh): Mexican midfielder is out of action with a hamstring strain.