Fantasy football bosses across the world wince when one of their star players hits the deck — and a spell in the treatment room is never good news.
Keep this page bookmarked to stay up to date with all the Premier League injuries and expected return dates throughout the season.
Kieran Tierney (knee): Requires surgery and will not be seen until next term.
Thomas Partey (thigh): Has begun his recovery but is expected to miss the rest of the season.
Takehiro Tomiyasu (thigh): A doubt for the final day after limping off against Newcastle.
Ezri Konsa (knee): Ruled out for up to four months after a knee injury against Crystal Palace.
Leon Bailey (ankle): Steven Gerrard is hopeful he will return against Manchester City.
Kortney Hause (abdominal): Still not available after missing recent games.
Ethan Pinnock (hamstring): The defender's season is over.
Saman Ghoddas (ankle): Is back running after spraining his ankle.
Frank Onyeka (ankle): Has a chance to feature against Leeds on Sunday.
Mathias Jorgensen (unknown): Will not feature again this season.
Jeremy Sarmiento (hamstring): Spent more time than expected on the sidelines and will likely miss out against West Ham.
Jakub Moder (knee): Faces a long time on the sidelines after picking up an ACL injury.
Enock Mwepu (groin): Midfielder is set to return for the Seagulls' final game.
Ben Mee (leg): Will be assessed as the Clarets look to secure survival against Newcastle.
Jay Rodriguez (hamstring): Missed Thursday's trip to Villa but could return on Sunday.
Johann Berg Gudmundsson (calf): Suffered a tear in his calf and is set for a lengthy absence.
Ashley Westwood (ankle): Suffered a gruesome injury at West Ham and will likely miss a lengthy period of time.
Matej Vydra (knee): Out for the long haul after rupturing his ACL.
Matt Lowton (suspended): Right-back will be absent on Sunday after his red card against Villa.
Erik Pieters (knee): Injury is not serious but is 50-50 for the Magpies clash.
Callum Hudson-Odoi (calf): Absent with a calf problem he picked up in early March.
Ben Chilwell (knee): Left-back is expected to be out for the rest of the season after a knee operation.
Timo Werner (thigh): Forward has missed Chelsea's last two games and may not feature against Watford.
Mateo Kovacic (ankle): Midfielder is a doubt for the weekend.
James McArthur (calf): May play the final game of the season.
Nathan Ferguson (hamstring): Suffered a setback in his recovery after missing a lengthy period of time.
James Tomkins (muscular): WIll have a late fitness test ahead of Sunday.
Michael Olise (foot): Is a doubt after missing Palace's last two games.
Nathan Patterson (ankle): Likely to miss the remainder of Everton's relegation fight after seeing a specialist.
Yerry Mina (calf): May return for the final day trip to Arsenal.
Fabian Delph (unknown): Unlikely to feature on the final day.
Andros Townsend (knee): Injured his ACL in the FA Cup defeat at Crystal Palace and will miss the rest of the season.
Jarrad Branthwaite and Salomon Rondon (both suspension): The pair's seasons are over after red cards against Brentford.
Tyler Roberts (thigh): Out for the rest of the season following surgery.
Patrick Bamford (foot): Making progress but is touch-and-go to appear again this season.
Adam Forshaw (knee): Suffered a fractured knee cap in training and will not feature until August.
Crysencio Summerville (ankle): Picked up an injury in training and is done for the season.
Stuart Dallas (thigh): Facing a lengthy period on the sidelines after suffering a femoral fracture.
Luke Ayling (suspended): Red card at Arsenal sees him suspended for the run-in.
Daniel James (suspended): Like Ayling, a rash tackle against Chelsea means he will take no further part in the relegation battle.
Ryan Bertrand (knee): Ruled out for most of the season after undergoing surgery.
Wilfried Ndidi (knee): Sidelined with a knee injury that will keep him out for the rest of the season.
Youri Tielemans (knee): Missed Chelsea game through injury but should be fit to face Southampton.
James Justin (illness): Hoping to recover for the final weekend.
Fabinho (hamstring): May not feature as Liverpool try to seal the title against Wolves.
Mohamed Salah (groin): Has been rested as a precaution but should be fit on Sunday.
Virgil van Dijk (knee): Influential defender will be assessed ahead of the Anfield clash.
Joe Gomez (ankle): Was withdrawn in midweek against Southampton and has a 50-50 chance of being fit.
John Stones (thigh): Could make a surprise return against Aston Villa after training this week.
Kyle Walker (ankle): Like Stones, Walker could also feature.
Ruben Dias (thigh): Another City defender who will not be available to Pep Guardiola for the final two league games.
Jadon Sancho (illness): Could feature in the United's last game of the season after suffering with a bout of tonsillitis
Luke Shaw (leg): Faces an uphill task to feature on Sunday.
Paul Pogba (calf): Limped off against Liverpool and may have played his last game for the club.
Marcus Rashford (illness): Hoping to recover from bronchitis in time for the clash with Crystal Palace.
Eric Bailly (back): Should be available for the trip to Selhurst Park.
Phil Jones (unknown): Faces missing out with an unspecified knock.
Chris Wood (groin): Will test his injury in training on Friday and a late call will be made.
Ryan Fraser (thigh): Returned to training and may yet play in the finale.
Isaac Hayden (knee): Not included in Eddie Howe's 25-man squad for the rest of the campaign.
Jonjo Shelvey (calf): A serious calf problem will rule him out of Newcastle's remaining games.
Joe Willock (knee): After injections got him through some games, Willock is now sidelined until the 2022-23 campaign.
Fabian Schar (head): Protocol is being followed after a head injury against Arsenal so faces a late decision for the Burnley trip.
Federico Fernandez (Achilles): Unlikely to feature.
Jamal Lewis (groin): Struggling with a long-term injury and has been taken out of action.
Adam Idah (knee): Has been ruled out for the rest of the season.
Andrew Omobamidele (back): Has been sent to a consultant to check the severity of his injury and will not be back until the Championship kicks off.
Ben Gibson (back): Defender has not trained since last week but could return tomorrow ahead of Tottenham clash.
Billy Gilmour (ankle): Returned to Chelsea after rolling his ankle but could be fit for the final game.
Christoph Zimmermann (hip): Picked up a hip problem in training and remains a doubt.
Kenny McLean (ankle): Midfielder's season is over.
Joshua Sargent (ankle): The American will miss the rest of the season.
Mathias Normann (thigh): Midfielder could return for Norwich's final Premier League before relegation.
Ozan Kabak (hamstring): Loanee has returned to parent club Schalke to get treatment.
Tino Livramento (knee): Ruptured his ACL at Brighton and faces a long spell out.
Romain Perraud (foot): Frenchman's season is over.
Fraser Forster (back): Will not be available to Ralph Hasenhuttl for the final day.
Japhet Tanganga (knee): Defender will miss the rest of the season after undergoing surgery.
Harry Kane (illness): Star striker is a doubt after not training with team-mates ahead of their top-four-deciding clash with Norwich.
Matt Doherty (knee): Full-back has been ruled out for the rest of the season following a challenge by Matty Cash against Aston Villa.
Sergio Reguilon (groin): Likely to join his Spurs team-mates on the sidelines for the remainder of the season.
Christian Romero (hip): Defender is unlikely to be fit as Spurs look to clinch fourth at Norwich.
Oliver Skipp (groin): Has undergone surgery and is out for the rest of the season.
Cucho Hernandez (hamstring): Progressing well and may be fit for the weekend.
Tom Cleverley (rib): Faces a late fitness test ahead of this weekend.
Nicolas Nkoulou (groin): May be back for the Chelsea clash.
Josh King and Kiko Femenia (illness): Pair are hoping to recover for the trip to Stamford Bridge.
Juraj Kucka (knee): Midfielder will miss Watford's final game.
Imran Louza (knee): Had surgery and will not play again this season.
Emmanuel Dennis (knee): Has a small chance of playing against the Blues.
Ismaila Sarr (knee): Like Dennis, will be assessed late on.
Angelo Ogbonna (knee): Influential defender has returned to training but is unlikely to feature before the season's end.
Said Benrahma (ankle): The knock he took last week will keep him out.
Max Kilman (knock): Ruled out for the weekend with an unspecified knock.
Nelson Semedo (thigh): Will watch the rest of the campaign from the sidelines.
Romain Saiss (other): Picked up a knock and is unsure on his return.