City begin Premier League title defence at West Ham
Champions Manchester City kick off their Premier League title defence with a potential banana skin at West Ham on August 7.
Having often punched above their weight last season, the Hammers will fancy their chances of causing an upset on home soil.
While that game is arguably the highlight of the opening weekend, the English top flight swings back into action when Crystal Palace take on Arsenal on August 5.
Bournemouth begin their campaign with a home match against Aston Villa on August 6, while fellow newcomers Fulham face a daunting clash against Liverpool at Craven Cottage earlier that day.
And all eyes will be on Championship play-off winners Nottingham Forest when they face Eddie Howe's Newcastle at St James' Park.
In the remaining fixtures on the first Saturday of the season, Leeds and Wolves collide at Elland Road, Tottenham face Southampton at the Tottenham Hotspur Stadium and Chelsea head to Everton in the evening kick-off.
In addition to City's clash with the Hammers, the first Super Sunday of the season will see Manchester United host Brighton at Old Trafford in a 2pm kick-off, while Leicester take on Brentford at the King Power Stadium at the same time.
Matchday 1 TV fixtures
Friday, August 5
Crystal Palace vs Arsenal (8pm, Sky Sports)
Saturday, August 6
Fulham vs Liverpool (12.30pm, BT Sport)
Everton vs Chelsea (5.30pm, Sky Sports)
Sunday, August 7
Manchester United vs Brighton (2pm, Sky Sports)
West Ham vs Manchester City (4.30pm, Sky Sports)
Premier League key dates
The 2022-23 Premier League season kicks off on August 5 when Crystal Palace and Arsenal collide in a London derby.
There will be a mid-season break after the weekend of November 12-13 to accommodate the World Cup.
Qatar 2022 runs from November 21-December 18 and the Premier League resumes on Boxing Day.
The Premier League season concludes on May 28, 2023, when all 10 games will kick off simultaneously.