The Fifth Test between England and India at Old Trafford has been called off due to fears of rising coronavirus cases in the tourists' camp.
The start of the final match in the series had been in doubt after India cancelled a practice session on Thursday as a result of a member of their support staff testing positive for COVID-19.
England had been hopeful of the contest, which was due to begin at 11am BST, going ahead as planned.
But after talks between the England and Wales Cricket Board (ECB) and their Board of Control for Cricket in India (BCCI) counterparts, the match has been cancelled.
"Following ongoing conversations with the BCCI, the ECB can confirm that the fifth LV= Insurance Test between England and India men due to start today at Emirates Old Trafford, will be cancelled," an ECB statement read.
"Due to fears of a further increase in the number of COVID cases inside the camp, India are regrettably unable to field a team.
"We send our sincere apologies to fans and partners for this news, which we know will cause immense disappointment and inconvenience to many."
The statement initially said India had forfeited the final Test and the series was drawn at 2-2, but that was later removed. The International Cricket Council will now determine the outcome of the match and series result.
India head coach Ravi Shastri tested positive for coronavirus during last week's 157-run win at The Oval, which gave his side a 2-1 lead in the five-Test series, while bowling coach Bharat Arun, fielding coach R Sridhar and physio Nitin Patel isolated as a precautionary measure.
The overall number of positive cases climbed this week after another backroom staff member, reported to be a junior physio, also contracted the respiratory disease.
The entire India squad returned negative PCR Tests on Thursday, though any hopes of rescheduling the match appear unlikely given the start of the Indian Premier League on September 19, four days after the England series was due to finish.