Women's FA Cup holders Chelsea face away day at Reading
Holders Chelsea will travel to Reading in the Women's FA Cup quarter-finals on March 19.
Emma Hayes' side are targeting a third successive title and fifth overall having dispatched Arsenal 2-0 in the fifth round.
Lewes, the lowest-ranked team left in the competition, host Women's Super League leaders Manchester United in what will be their first appearance in the quarters.
Alongside Lewes, Birmingham City are the second Women's Championship side still left in the tournament and they face Brighton at home.
Completing the draw is Manchester City's visit to Aston Villa.
Women's FA Cup quarter-final draw
Reading vs Chelsea
Aston Villa vs Manchester City
Lewes vs Manchester United
Birmingham City vs Brighton
All ties to be played on Sunday, March 19.