Thomas Frank's Brentford earned their second league win of the season after a 2-0 victory at Molineux.
The Bees took the lead just before the half-hour mark via an Ivan Toney penalty he after wrestled to the ground by Wolves captain Conor Coady.
Brentford almost doubled their lead instantly after Toney flicked the ball into the net from point-blank range, before VAR disallowed the goal due to a handball.
The away side did however get their second of the game shortly after. Toney broke in behind the Wolves defence before playing the ball into the path of Bryan Mbuemo - who slotted the ball into the open net.
The Bees were reduced to 10 men in the second half, after Shandon Baptiste was sent off after a number of cynical fouls but Wolves could not get back into the game.
Frank was delighted after his side's victory. He said: "These players are amazing and they keep, surprising me isn’t the word, but impressing me.
“It was a very impressive, brave performance. In the second half we were down to 10 men but we defended with our heart and soul.
"We gave only one big chance away and that’s very impressive.”
Did you know?
Wolves have lost nine home Premier League games in 2021, more than any other current side in the division.
Wolves have lost four of their first five league games of a top-flight season for the sixth time in their history and for the first time since their 2003-04 Premier League campaign which ended in relegation.
Brentford are the 14th promoted side in Premier League history to accrue 8-plus points after five games, and the first since Wolves in 18-19.
Only West Ham (zero) have made fewer starting XI changes in their Premier League games so far this season than both Wolves (wolves) and Brentford (two).
Since their return to the Premier League in 2018-19, Wolves have seen their opponents pick up 16 red cards, more than any other side in that time.
Ivan Toney has scored 15 of the 16 penalties he has taken in English league football, including all 10 for current club Brentford.
Since the start of last season, Toney has scored 33 goals, more than any other player in the top four tiers of English football.