Raphael Varane was handed his Manchester United debut in Sunday's Premier League clash with Wolves, while Jadon Sancho was included in the starting line-up for the first time.
United officially completed the signing of Varane from Real Madrid two weeks ago and the centre-back was an unused substitute in last week's 1-1 draw with Southampton.
Sancho had made two substitute appearances since arriving from Borussia Dortmund, meanwhile, playing a combined 46 minutes in the Red Devils' opening two league games.
Victor Lindelof and Anthony Martial dropped out of the side from the draw at St Mary's to make way for Varane and Sancho respectively.
The omission of Daniel James was the third change made by Ole Gunnar Solskjaer, with Nemanja Matic coming into the side for the showdown at Molineux.
Paul Pogba once again started and was looking to build on an impressive start to 2021-22 that included five assists in his first two outings – the most by a Premier League player at this stage.
Cristiano Ronaldo will have to wait to make the first appearance of his second spell for United as his high-profile switch from Juventus has yet to officially go through.
Edinson Cavani was in contention to feature for the first time this season at Molineux as a substitute after being given an extended break following his Copa America exertions with Uruguay.
Wolves boss Bruno Lange named the same starting line-up that fell to a 1-0 loss to Tottenham last week, meanwhile, but Willy Boly and Daniel Podence were back among the substitutes.
United had lost just one of their last eight Premier League meetings with Wolves heading into Sunday's contest, going down 2-1 at Molineux in April 2019.