Prithvi Shaw and Suryakumar Yadav have been called up to India's squad for the Test series against England after Washington Sundar, Shubman Gill and Avesh Khan were ruled out.
All-rounder Sundar misses out due to finger injury on his bowling hand that will take longer than expected to recover from.
Gill suffered a stress fracture of his shin during the World Test Championship final defeat to New Zealand at the Ageas Bowl and the opening batsman has returned to India.
Paceman Khan fractured his thumb during a warm-up game against a County Select XI last week.
Batsmen Shaw and Yadav - uncapped in the longest format - have been drafted in as replacements, while Prasidh Krishna and Arzan Nagwaswalla are on standby.
Wicketkeeper-batsman Rishabh Pant has been reunited with his team-mates after recovering from coronavirus.
The five-match series starts at Trent Bridge next Wednesday.
India squad: Rohit Sharma, Mayank Agarwal, Cheteshwar Pujara, Virat Kohli (captain), Ajinkya Rahane, Hanuma Vihari, Rishabh Pant, Ravichandran Ashwin, Ravindra Jadeja, Axar Patel, Jasprit Bumrah, Ishant Sharma, Mohammed Shami, Mohammed Siraj, Shardul Thakur, Umesh Yadav, KL Rahul, Wriddhiman Saha, Abhimanyu Easwaran, Prithvi Shaw, Suryakumar Yadav.