Real Madrid will face Barcelona's conquerors Athletic Bilbao in the pick of the Copa del Rey quarter-final ties.
The one-legged fixture at San Mames is a repeat of last week's Supercopa de Espana final, which Madrid won 2-0 to secure the first silverware of Carlo Ancelotti's second spell.
Madrid will now look to take advantage of record 31-time winners Barca's last-16 exit to Athletic, with Iker Muniain's extra-time penalty eliminating the holders in a 3-2 defeat.
Friday's draw, which was conducted by Spain legend David Villa, also pitted LaLiga high-flyers Real Sociedad and Real Betis.
Betis are third in the Spanish top flight after enjoying a sensational campaign thus far, while Sociedad are fifth and themselves in contention for a Champions League spot.
Valencia will take on Cadiz, meanwhile, and Rayo Vallecano are up against Real Mallorca in the other all-LaLiga quarter-final fixture.
All four ties will take place in two weeks' time, with the first leg of the semi-finals scheduled for the following week.
Copa del Rey quarter-final draw in full:
Athletic Bilbao v Real Madrid
Real Sociedad v Real Betis
Valencia v Cadiz
Rayo Vallecano v Real Mallorca