Away day specialists Manchester United make the short hop across to face bitter rivals Leeds in Sunday’s standout fixture.
As well as that enticing prospect, two relegation-threatened sides travel to mid-table opponents in the hunt for precious points.
Burnley could take a giant stride towards safety with a result at improving Wolves, while West Brom need three points from their local derby with Aston Villa.
Wolves vs Burnley (12pm, BBC One)
Wolves will be out to make it three straight wins for the first time this season when they welcome struggling Burnley to Molineux.
Nuno Espirito Santo’s men have long been destined for mid-table this term after an eight-game winless run at the turn of the year ended hopes of a European charge.
Back-to-back 1-0 victories over relegation strugglers Fulham and doomed Sheffield United means that an outside chance of a top-half finish remains but they've won only one of their last nine league meetings with the Clarets, who head to the West Midlands still entrenched in the relegation battle.
Sean Dyche has seen his side squander leads against both Southampton and Newcastle before coming unstuck late on against Manchester United last Sunday to make it three straight defeats.
But Fulham's poor form means a win here would pull them nine points clear of the Cottagers and virtually guarantee them Premier League football at Turf Moor again next year.
Wolves are still without Ruben Neves (coronavirus) while the visitors are without Ashley Barnes (thigh) and Robbie Brady (Achilles) — though Nick Pope (shoulder) is close to a return in goal.
Leeds vs Manchester United (2pm, Sky Sports)
Old rivalries will be renewed as Leeds host Manchester United in a top-flight home game for the first time since October 2003.
It was a disappointing reverse meeting for Marcelo Bielsa’s Whites, humbled 6-2 at Old Trafford in December — though the Mancunians have only managed to do the double over them twice in 12 previous Premier League attempts.
Having taken four points from clashes against Manchester City and Liverpool in their previous two outings, the hosts will hold no fear of their opponents as they look to secure a top-half finish.
Ole Gunnar Solskjaer’s visitors appear assured of Champions League qualification but find themselves too far behind City in the title race, meaning their focus will now likely be on securing second spot.
Their remarkable run on the road — 23 Premier League away games without defeat stretching back to January 2020 — is now only four matches behind the league record of Arsenal (27).
Red Devils forward Mason Greenwood has four goals in his last three Premier League appearances and can become the first teenager to score in four straight top-flight games since Francis Jeffers in September 2000.
Liam Cooper is suspended for the hosts but both Raphinha (knock) and Rodrigo (muscle strain) could return. The visitors have no fresh issues.
Aston Villa vs West Brom (7pm, BT Sport)
The weekend’s action rounds off with a West Midlands derby, where Aston Villa could inflict a near fatal blow to West Brom’s survival prospects.
What started as an extremely promising campaign for Villa has rather petered out, with only two wins in their last 10 league outings killing hopes of a top-six charge.
Having won the reverse fixture 3-0 at the Hawthorns in December, Dean Smith’s hosts could complete a first league double over their neighbours since 2008-09 — a season which also saw the Baggies relegated to the Championship.
Sam Allardyce’s men were threatening the greatest of escapes after back-to-back wins over Chelsea and Southampton but were then comfortably dispatched 3-0 at Leicester on Thursday.
A win here is vital and they can take heart from having won on their last two trips to Villa Park — hoping to make it three consecutive victories for the first time since 1902.
Discipline has been an issue for the Baggies in this fixture recently however, having had a player sent off in each of their last three clashes with the Villans.
Matty Cash is suspended for the home side while Jack Grealish (shin) is still working his way back to fitness. The visitors, meanwhile, may welcome back Robert Snodgrass (knee)