Manchester City can secure the Premier League title when they face Chelsea in a Champions League final dress rehearsal — the highlight of a packed Saturday of action in England’s top flight.
Elsewhere, Tottenham and Liverpool will look for precious wins to maintain their European hopes, while Crystal Palace can mathematically assure their safety.
Leeds vs Tottenham (12.30pm, BT Sport)
Tottenham will hunt a fourth straight victory over Leeds as they look to keep alive their faint hopes of a top-four finish.
Since winning six consecutive meetings between 1999 and 2001 in the Premier League, Leeds are without a top-flight victory over Spurs and were humbled 3-0 in North London back in January.
However, Marcelo Bielsa’s men still harbour hopes of a top-half finish and were on a six-game unbeaten run prior to last weekend’s disappointing 2-0 defeat at Brighton.
Spurs caretaker boss Ryan Mason has made an excellent start to life in the dugout and can become the first manager in the club’s history to win his first three Premier League outings with a win at Elland Road.
Mason's troops enter the contest five points behind fourth-placed Chelsea. But with the Blues facing the champions-elect later in the day, the visitors must be ready to capitalise on any dropped points.
Real Madrid loanee Gareth Bale’s brilliant hat-trick against Sheffield United last Sunday means he only needs one more strike to reach double figures in the Premier League for the first time since 2013.
The hosts are sweating over the fitness of both Kalvin Phillips (knee) and Raphinha (knock), while Spurs have no fresh injury concerns.
Sheffield United vs Crystal Palace (3pm, Sky Sports)
Crystal Palace make the long trip to Sheffield United in an end-of-season dead rubber.
Although Palace's Premier League status is still not mathematically assured, that will change with a victory at Bramall Lane — or as soon as Fulham drop another point if they lose.
With a host of contracts expiring this summer, including that of boss Roy Hodgson, wholesale changes appear likely at Selhurst Park ahead of what will be their ninth straight campaign in the top tier.
There will be no such luck for the Blades, who have long known their fate and will already have one eye on bouncing straight back from the Championship.
They are currently under the guidance of caretaker boss Paul Heckingbottom, who is thought to be one of the five remaining candidates on the club’s shortlist to take the role permanently in the summer.
An impressive win over Brighton last month will have done no harm to his prospects of landing the role, but last week’s 4-0 thumping at the hands of Tottenham saw his beleaguered side brought crashing back down to earth with a bang.
Ethan Ampadu (calf) should return for the hosts and none of Palace’s absentees are likely to feature.
Manchester City vs Chelsea (5.30pm, Sky Sports)
Exactly three weeks before they are set to meet in the Champions League final, Manchester City and Chelsea lock horns at the Etihad — with the hosts knowing a win will secure a fifth Premier League title in 10 seasons.
Having dismantled Paris Saint-Germain on Tuesday evening, Pep Guardiola’s men will look to top off a sensational week with three points that would take them out of the reach of closest rivals Manchester United.
It will be City’s third clash with the Blues this term. They won the reverse league meeting 3-1 at Stamford Bridge during Frank Lampard’s reign before seeing their quadruple hopes dashed by Thomas Tuchel’s troops at Wembley in last month’s FA Cup semi-final, which the Blues won 1-0.
While the hosts have the champagne on ice, a victory is also paramount for Chelsea if they are to maintain their spot in the top four.
It has been a remarkable start to life in London for Tuchel — the Blues have lost only one of his 15 league outings under him while also reaching the FA Cup and Champions League finals.
Clean sheets have been key to his success with yet another impressive shutout against Real Madrid in midweek — and a win without conceding here would mark three straight shutout victories in the Premier League for the first time since November 2017.
City are without the suspended John Stones and Chelsea are likely to still be missing Mateo Kovacic (hamstring).
Liverpool vs Southampton (8.15pm, Sky Sports)
Liverpool can ill afford any more slip-ups if they are to feature in European competition next season, with Southampton the visitors to Anfield in Sunday's finale.
Consecutive 1-1 draws against Leeds and Newcastle have left the Reds needing favours from those above them if they are to get back into the top four — and even a top-six finish is far from assured at this stage.
Jurgen Klopp has seen his side endure home woes on a scale that would have been previously unthinkable, having taken a miserly six points from a possible 30 at Anfield in a run stretching back to late December.
They will lnow ook to exact revenge on Ralph Hasenhuttl’s Saints, who inflicted a 1-0 defeat on the Merseysiders at St Mary’s back in January — at a time when the Reds still topped the table.
It has also not been a happy second half of the campaign for Southampton, who have lost 12 of their 16 league outings since that memorable victory and plummeted down the table in the process.
With safety assured, the Saints have little to play for but will be keen to complete a league double over their opponents for only the second time in the last 60 years.
Both sides have seen their campaigns heavily impacted by injuries and none of their sidelined stars are set for a return — though former Reds forward Danny Ings (hamstring) could make the bench for the visitors.