Fantasy football bosses across the world wince when one of their star players hits the deck — and a spell in the treatment room is never good news.
Keep this page bookmarked to stay up to date with all the Premier League injuries and expected return dates throughout the season.
Rob Holding (suspended): Will miss the Newcastle trip after his North London derby red card.
Kieran Tierney (knee): Requires surgery and will not be seen until next term.
Thomas Partey (thigh): Has begun his recovery but is expected to miss the rest of the season.
Gabriel (thigh): Limped off at Spurs with a muscle problem.
Leon Bailey (ankle): Club remain hopeful he will be back for the Crystal Palace clash.
Jacob Ramsey (unknown): Youngster could well return to the squad after missing the Liverpool defeat.
Ollie Watkins (other): Will be touch-and-go for the Palace match.
Kortney Hause (abdominal): Still not available after missing recent games.
Ethan Pinnock (hamstring): Could return after missing the Bees' recent games.
Sergi Canos (hamstring): He may feature after recovering from his hamstring injury.
Saman Ghoddas (ankle): Is back running after spraining his ankle.
Frank Onyeka (ankle): An ankle ligament injury will keep him out for the remainder of the campaign.
Mathias Jorgensen (unknown): Will not feature again this season.
Jeremy Sarmiento (hamstring): Spent more time than expected on the sidelines so should return at Leeds.
Jakub Moder (knee): Faces a long time on the sidelines after picking up an ACL injury.
Enock Mwepu (groin): Midfielder's season is likely to be over due to his groin injury.
Ben Mee (leg): Back on the grass but Sunday's visit to Spurs will come to soon.
Jay Rodriguez (hamstring): Is a doubt for Sunday but will be assessed late on.
James Tarkowski (hamstring): Is facing a fitness test after feeling his hamstring against Aston Villa.
Johann Berg Gudmundsson (calf): Suffered a tear in his calf and is set for a lengthy absence.
Ashley Westwood (ankle): Suffered a gruesome injury at West Ham and will likely miss a lengthy period of time.
Matej Vydra (knee): Out for the long haul after rupturing his ACL.
Chelsea (In FA Cup action)
Callum Hudson-Odoi (calf): Absent with a calf problem he picked up in early March.
Ben Chilwell (knee): Left-back is expected to be out for the rest of the season after a knee operation.
James McArthur (calf): May play the final game of the season.
Marc Guehi (ankle): Likely to miss the Villa trip due to his ankle problem.
Vicente Guaita (calf): The Eagles' No1 may return after missing last week's game.
Nathan Ferguson (hamstring): Suffered a setback in his recovery after missing a lengthy period of time.
Nathan Patterson (ankle): Likely to miss the remainder of Everton's relegation fight after seeing a specialist.
Yerry Mina (calf): May return for the final day trip to Arsenal next weekend.
Ben Godfrey (thigh): Remains out with his thigh problem.
Donny van de Beek (groin): Will miss the Brentford game but could play in midweek.
Fabian Delph (unknown): Being assessed due to an unknown issue.
Andros Townsend (knee): Injured his ACL in the FA Cup defeat at Crystal Palace and will miss the rest of the season.
Tyler Roberts (thigh): Out for the rest of the season following surgery.
Patrick Bamford (foot): Making progress but is touch-and-go to appear again this season.
Adam Forshaw (knee): Suffered a fractured knee cap in training and will not feature until August.
Crysencio Summerville (ankle): Picked up an injury in training ahead of the trip to Crystal Palace.
Stuart Dallas (thigh): Facing a lengthy period on the sidelines after suffering a femoral fracture.
Luke Ayling (suspended): Red card at Arsenal sees him suspended for the run-in.
Daniel James (suspended): Like Ayling, rash tackle against Chelsea means he will take no further part in the relegation battle.
Wesley Fofana (calf): Missed the midweek clash due to a tight calf but should return.
Ricardo Pereira (thigh): Will miss the weekend's action and may not feature again.
Ryan Bertrand (knee): Ruled out for most of the season after undergoing surgery.
Wilfried Ndidi (knee): Sidelined with a knee injury that will keep him out for the rest of the season.
Fabinho (hamstring): May not feature in the Premier League again this season after limping off at Aston Villa.
John Stones (thigh): His thigh injury will keep him out until pre-season.
Kyle Walker (ankle): Like Stones, Walker will not play again in May.
Ruben Dias (thigh): Another City defender who will not be available to Pep Guardiola for the final two league games.
Aymeric Laporte (knee): Limped off after taking a knock to the knee at Wolves and is a doubt for the West Ham trip.
Fernandinho (unknown): City's makeshift centre-half looks a doubt for Sunday.
Manchester United (No game)
Jadon Sancho (illness): May not feature again this season after suffering with a bout of tonsillitis
Luke Shaw (leg): Faces an uphill task to feature again this season.
Paul Pogba (calf): Limped off against Liverpool and may have played his last game for the club.
Ryan Fraser (thigh): Returned to training and may yet play in the next week.
Isaac Hayden (knee): Not included in Eddie Howe's 25-man squad for the rest of the campaign.
Jonjo Shelvey (calf): A serious calf problem will rule him out of Newcastle's remaining games.
Joe Willock (knee): After injections got him through some games, Willock is now sidelined until the 2022-23 campaign.
Fabian Schar (ankle): Has not trained since injury against Liverpool but could still feature versus the Citizens.
Federico Fernandez (Achilles): Unlikely to feature.
Jamal Lewis (groin): Struggling with a long-term injury and has been taken out of action.
Adam Idah (knee): Has been ruled out for the rest of the season.
Andrew Omobamidele (back): Has been sent to a consultant to check the severity of his injury and will not be back until the Championship kicks off.
Christoph Zimmermann (hip): Picked up a hip problem in training and remains a doubt.
Kenny McLean (ankle): Midfielder's season is over.
Joshua Sargent (ankle): Despite returning last week against Aston Villa, the American will miss the rest of the season.
Mathias Normann (thigh): Has had to go for a scan on a thigh problem and is a doubt.
Ozan Kabak (hamstring): Loanee has returned to parent club Schalke to get treatment.
Tino Livramento (knee): Ruptured his ACL at Brighton and faces a long spell out.
Japhet Tanganga (knee): Defender will miss the rest of the season after undergoing surgery.
Matt Doherty (knee): Full-back has been ruled out for the rest of the season following a challenge by Matty Cash against Aston Villa.
Sergio Reguilon (groin): Likely to join his Spurs team-mates on the sidelines for the remainder of the season.
Christian Romero (hip): Will require a late fitness test after missing the North London derby.
Oliver Skipp (groin): Has undergone surgery and is out for the rest of the season.
Cucho Hernandez (hamstring): Progressing well but not fit for the weekend.
Tom Cleverley (rib): Faces a kate fitness test ahead of this weekend.
Nicolas Nkoulou (groin): May be back for the Leicester clash.
Juraj Kucka (knee): Being assessed ahead of Sunday's match.
Imran Louza (knee): Had surgery and will not play again today.
Emmanuel Dennis (knee): Has a small chance of playing against Leicester.
Ismaila Sarr (knee): Like Dennis, will be assessed late on.
Michail Antonio (hip): took a knock last time out but should be ready to go.
Craig Dawson (calf): Took a blow to the calf and is a doubt.
Angelo Ogbonna (knee): Influential defender has returned to training but is unlikely to feature before the season's end.
Said Benrahma (ankle): The knock he took last week will keep him out.
Daniel Podence (foot): Forward's foot injury is keeping him sidelined.
Max Kilman (knock): Ruled out for the weekend with an unspecified knock.
Nelson Semedo (thigh): Will watch the rest of the campaign from the sidelines.
Romain Saiss (other): Picked up a knock and is unsure on his return.